Virtually all adults with Down syndrome (DS) show the neuropathological changes of
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …

Background A new paradigm is emerging in which mobility and cognitive impairments,
previously studied, diagnosed, and managed separately in older adults, are in fact regulated …

Background Motor and cognitive impairments are frequently observed following stroke, but
are often managed as distinct entities, and there is little evidence regarding how they are …

Abstract Changes in gait, especially decreased gait velocity, may be a harbinger of cognitive
decline in aging. Motoric cognitive risk syndrome (MCR), a pre-dementia syndrome …

Dementia is characterized by a long preclinical phase that may last years to decades before
the onset of mild cognitive impairment. Slow gait speed and subjective memory complaint …

Importance Dual decline in both memory and gait speed may characterize a group of older
individuals at high risk for future dementia. Objective To assess the risk of dementia in older …

Background: Cognitive frailty (CF), defined as the simultaneous presence of cognitive
impairment and physical frailty, is a clinical symptom in early-stage dementia with promise in …

Abstract Background Motoric Cognitive Risk Syndrome (MCR), slow gait speed (SG) and
subjective cognitive decline (SCD) are known to be harbingers of dementia. MCR is known …

Background and purpose In older age, physical and cognitive declines have been shown to
occur simultaneously or consequent to one another, and several operational definitions …

We aimed to refine the hypothesis that motoric cognitive risk (MCR), a syndrome combining
measured slow gait speed and self‐reported cognitive complaints, is prognostic of incident …