Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) in human disease, an overview
MF Lindberg, L Meijer - International Journal of Molecular Sciences, 2021 - mdpi.com
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …
The omnipresence of DYRK1A in human diseases
E Deboever, A Fistrovich, C Hulme… - International journal of …, 2022 - mdpi.com
The increasing population will challenge healthcare, particularly because the worldwide
population has never been older. Therapeutic solutions to age-related disease will be …
population has never been older. Therapeutic solutions to age-related disease will be …
Diabetic kinome inhibitors—A new opportunity for β-cells restoration
Diabetes, and several diseases related to diabetes, including cancer, cardiovascular
diseases and neurological disorders, represent one of the major ongoing threats to human …
diseases and neurological disorders, represent one of the major ongoing threats to human …
Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation
Ribosomal proteins (RPs) are evolutionary conserved proteins that are essential for protein
translation. RP expression must be tightly regulated to ensure the appropriate assembly of …
translation. RP expression must be tightly regulated to ensure the appropriate assembly of …
Insights from the protein interaction Universe of the multifunctional “Goldilocks” kinase DYRK1A
V Ananthapadmanabhan, KH Shows… - Frontiers in Cell and …, 2023 - frontiersin.org
Human Dual specificity tyrosine (Y)-Regulated Kinase 1A (DYRK1A) is encoded by a
dosage-dependent gene located in the Down syndrome critical region of human …
dosage-dependent gene located in the Down syndrome critical region of human …
Selective DYRK1A inhibitor for the treatment of neurodegenerative diseases: Alzheimer, parkinson, huntington, and down syndrome
RB Kargbo - ACS medicinal chemistry letters, 2020 - ACS Publications
Biological Target. Dual specificity tyrosine phosphorylation regulated kinase-1 A (DYRK1A).
Summary. Alzheimer, s disease (AD) is the primary cause of dementia in the elderly, and the …
Summary. Alzheimer, s disease (AD) is the primary cause of dementia in the elderly, and the …
The DYRK1A protein kinase regulates ribosome mass and translation rates through transcriptional control of ribosomal protein genes expression
C Di Vona, L Barba, R Ferrari, S de la Luna - bioRxiv, 2021 - biorxiv.org
Ribosomal proteins (RPs) are evolutionary conserved proteins that are essential for protein
translation. RP expression must be tightly regulated, both to ensure the appropriate …
translation. RP expression must be tightly regulated, both to ensure the appropriate …