Biliary Atresia–emerging diagnostic and therapy opportunities
U Lendahl, VCH Lui, PHY Chung, PKH Tam - EBioMedicine, 2021 - thelancet.com
Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In
this review, we describe recent progress in the understanding of liver development with a …
this review, we describe recent progress in the understanding of liver development with a …
[PDF][PDF] Biliary atresia in children: update on disease mechanism, therapies, and patient outcomes
S Antala, SA Taylor - Clinics in liver disease, 2022 - Elsevier
Biliary atresia is a rare disease but remains the most common indication for pediatric liver
transplantation as there are no effective medical therapies to slow progression after …
transplantation as there are no effective medical therapies to slow progression after …
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia
SP Amarachintha, R Mourya, H Ayabe, L Yang… - …, 2022 - Wiley Online Library
Abstract Background and Aims Biliary atresia is a severe inflammatory and fibrosing
cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a …
cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a …
Matrix metalloproteinase-7 and osteopontin serum levels as biomarkers for biliary atresia
Objectives: Matrix metallopeptidase-7 (MMP-7) and osteopontin (OPN) are important
components in the pathophysiology of fibrosis in biliary atresia (BA). There has been much …
components in the pathophysiology of fibrosis in biliary atresia (BA). There has been much …
[HTML][HTML] CD177+ cells produce neutrophil extracellular traps that promote biliary atresia
R Zhang, L Su, M Fu, Z Wang, L Tan, H Chen, Z Lin… - Journal of …, 2022 - Elsevier
Background & aims We have previously reported on the potential pathogenic role of
neutrophils in biliary atresia (BA). Herein, we aimed to delineate the role of CD177+ …
neutrophils in biliary atresia (BA). Herein, we aimed to delineate the role of CD177+ …
Maternal regulation of biliary disease in neonates via gut microbial metabolites
Maternal seeding of the microbiome in neonates promotes a long-lasting biological footprint,
but how it impacts disease susceptibility in early life remains unknown. We hypothesized …
but how it impacts disease susceptibility in early life remains unknown. We hypothesized …
Dynamic analysis of serum MMP-7 and its relationship with disease progression in biliary atresia: a multicenter prospective study
S Chi, P Xu, P Yu, G Cao, H Wang, Y Ye, S Li… - Hepatology …, 2022 - Springer
Purpose We aimed to assess the dynamic changing trend of serum matrix metalloproteinase-
7 (MMP-7) in biliary atresia (BA) patients from diagnosis to LTx to further elucidate its clinical …
7 (MMP-7) in biliary atresia (BA) patients from diagnosis to LTx to further elucidate its clinical …
Refashioning benzothiadiazole dye as an activatable nanoprobe for biomarker detection with NIR-II fluorescence/optoacoustic imaging
J Chen, L Chen, Y Fang, F Zeng, S Wu - Cell Reports Physical Science, 2022 - cell.com
Endogenous nitric oxide is important for living beings; hence, accurate and non-invasive
detection of nitric oxide (NO) in situ is of significance. Benzothiadiazole-core chromophores …
detection of nitric oxide (NO) in situ is of significance. Benzothiadiazole-core chromophores …
TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia
C Short, A Zhong, J Xu, E Mahdi, A Glazier… - Hepatology, 2023 - journals.lww.com
TWEAK/FN14 promotes profibrogenic pathway activation in Prom... : Hepatology TWEAK/FN14
promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor …
promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor …
Predictive model containing gene signature and shear wave elastography to predict patient outcomes after Kasai surgery in biliary atresia
G Wang, H Chen, P Sun, W Zhou, H Jiang… - Hepatology …, 2023 - Wiley Online Library
Aims Infants with biliary atresia (BA) are treated with Kasai portoenterostomy (KPE) surgery,
but many BA patients need subsequent salvage liver transplants. The aim of this study is to …
but many BA patients need subsequent salvage liver transplants. The aim of this study is to …