Sex differences and similarities in valvular heart disease
JT DesJardin, J Chikwe, RT Hahn, JW Hung… - Circulation …, 2022 - Am Heart Assoc
As populations age worldwide, the burden of valvular heart disease has grown
exponentially, and so has the proportion of affected women. Although rheumatic valve …
exponentially, and so has the proportion of affected women. Although rheumatic valve …
Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review
Despite numerous promising therapeutic targets, there are no proven medical treatments for
calcific aortic stenosis (AS). Multiple stakeholders need to come together and several …
calcific aortic stenosis (AS). Multiple stakeholders need to come together and several …
Secreted factors from proinflammatory macrophages promote an osteoblast-like phenotype in valvular interstitial cells
Objective: Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic
valve stenosis progression, which further promotes fibrosis or even differentiate into …
valve stenosis progression, which further promotes fibrosis or even differentiate into …
Lipoprotein (a) is robustly associated with aortic valve calcium
Objectives To investigate the prevalence and quantity of aortic valve calcium (AVC) in two
large cohorts, stratified according to age and lipoprotein (a)(Lp (a)), and to assess the …
large cohorts, stratified according to age and lipoprotein (a)(Lp (a)), and to assess the …
Innate immune cells in the pathophysiology of calcific aortic valve disease: lessons to be learned from atherosclerotic cardiovascular disease?
W Broeders, S Bekkering, S El Messaoudi… - Basic Research in …, 2022 - Springer
Calcific aortic valve disease (CAVD) is the most common valvular disease in the developed
world with currently no effective pharmacological treatment available. CAVD results from a …
world with currently no effective pharmacological treatment available. CAVD results from a …
Lipoprotein (a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis
Objective To assess whether patients with aortic valve stenosis (AS) with elevated
lipoprotein (a)(Lp (a)) are characterised by increased valvular calcification activity compared …
lipoprotein (a)(Lp (a)) are characterised by increased valvular calcification activity compared …
Pathophysiology, emerging techniques for the assessment and novel treatment of aortic stenosis
Our perspectives on aortic stenosis (AS) are changing. Evolving from the traditional thought
of a passive degenerative disease, developing a greater understanding of the condition's …
of a passive degenerative disease, developing a greater understanding of the condition's …
Latest advances in multimodality imaging of aortic stenosis
E Tzolos, J Kwiecinski, D Berman… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Aortic stenosis is a common condition associated with major morbidity, mortality, and health-
care costs. Nevertheless, we currently lack any effective medical therapies that can treat or …
care costs. Nevertheless, we currently lack any effective medical therapies that can treat or …
A lipid droplets specific probe for imaging of atherosclerosis and fibrocalcific bicuspid aortic valves
Lipid droplets (LDs) have been regarded as potential targets for the diagnosis of
cardiovascular diseases. However, conventional LDs imaging strategies suffer from invasive …
cardiovascular diseases. However, conventional LDs imaging strategies suffer from invasive …
Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33
A Witz, D Effertz, N Goebel, M Schwab, UFW Franke… - Biomolecules, 2023 - mdpi.com
One of the contributors to atherogenesis is enzymatically modified LDL (eLDL). eLDL was
detected in all stages of aortic valve sclerosis and was demonstrated to trigger the activation …
detected in all stages of aortic valve sclerosis and was demonstrated to trigger the activation …