Establishing electron diffraction in chemical crystallography

T Gruene, JJ Holstein, GH Clever… - Nature Reviews Chemistry, 2021 - nature.com
The emerging field of 3D electron diffraction (3D ED) opens new opportunities for structure
determination from sub-micrometre-sized crystals. Although the foundations of this …

Porous organic compounds–small pores on the rise

T Kunde, T Pausch, BM Schmidt - European Journal of Organic …, 2021 - Wiley Online Library
Porous materials are important for various energy‐related technologies such as catalysis
and separation. While porous organic cage compounds are a rather recent addition to the …

Unraveling the Electrical and Magnetic Properties of Layered Conductive Metal‐Organic Framework With Atomic Precision

Z Meng, CG Jones, S Farid, IU Khan… - Angewandte Chemie …, 2022 - Wiley Online Library
This paper describes structural elucidation of a layered conductive metal‐organic framework
(MOF) material Cu3 (C6O6) 2 by microcrystal electron diffraction with sub‐angstrom …

MicroED as a powerful tool for structure determination of macrocyclic drug compounds directly from their powder formulations

E Danelius, G Bu, LHE Wieske, T Gonen - ACS Chemical Biology, 2023 - ACS Publications
Macrocycles are important drug leads with many advantages including the ability to target
flat and featureless binding sites as well as to act as molecular chameleons and thereby …

Hakuhybotrol, a polyketide produced by Hypomyces pseudocorticiicola, characterized with the assistance of 3D ED/MicroED

Y Watanabe, S Takahashi, S Ito, T Tokiwa… - Organic & …, 2023 - pubs.rsc.org
A new polyketide, named hakuhybotrol (1), was isolated from a cultured broth of the
mycoparasitic fungus Hypomyces pseudocorticiicola FKA-73, together with six known …

An overview of microcrystal electron diffraction (MicroED)

X Mu, C Gillman, C Nguyen… - Annual review of …, 2021 - annualreviews.org
The bedrock of drug discovery and a key tool for understanding cellular function and drug
mechanisms of action is the structure determination of chemical compounds, peptides, and …

Advanced high-resolution chromatographic strategies for efficient isolation of natural products from complex biological matrices: from metabolite profiling to pure …

EF Queiroz, D Guillarme, JL Wolfender - Phytochemistry Reviews, 2024 - Springer
The isolation of pure compounds from extracts represents a key step common to all
investigations of natural product (NP) research. Isolation methods have gone through a …

From relative to absolute stereochemistry of secondary metabolites: Applications in plant chemistry

R Pereda-Miranda, E Bautista… - Revista Brasileira de …, 2023 - Springer
Structural elucidation of specialized metabolites or natural plant products, especially the
stereochemical features of chiral bioactive metabolites, is the most important stage for all …

Acidic cannabinoid decarboxylation

CN Filer - Cannabis and Cannabinoid Research, 2022 - liebertpub.com
Introduction: Cannabis is a valuable plant, cultivated by humans for millennia. However, it
has only been in the past several decades that biologists have begun to clarify the …

Similarities in Diverse Polycyclic Aromatic Hydrocarbons of Asphaltenes and Heavy Oils Revealed by Noncontact Atomic Force Microscopy: Aromaticity, Bonding, and …

Y Zhang - Chemistry Solutions to Challenges in the Petroleum …, 2019 - ACS Publications
Heavy oils are enriched in polycyclic aromatic hydrocarbons (PAHs)(or polynuclear aromatic
hydrocarbons), but characterization of their chemical structures has been a great challenge …