A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

RS Keri, MR Patil, SA Patil, S Budagumpi - European Journal of Medicinal …, 2015 - Elsevier
Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …

Thiazole: A promising heterocycle for the development of potent CNS active agents

CB Mishra, S Kumari, M Tiwari - European journal of medicinal chemistry, 2015 - Elsevier
Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to
display a variety of biological activities. Thiazole and its derivatives have attracted …

Effects of replacing oxygenated functionality with fluorine on lipophilicity

RJ Glyn, G Pattison - Journal of Medicinal Chemistry, 2021 - ACS Publications
The replacement of oxygenated functionality (hydroxy and alkoxy) with a fluorine atom is a
commonly used bioisosteric replacement in medicinal chemistry. In this paper, we use …

Biological aspects of emerging benzothiazoles: a short review

R Ali, N Siddiqui - Journal of chemistry, 2013 - Wiley Online Library
In recent years heterocyclic compounds analogues and derivatives have attracted wide
attention due to their useful biological and pharmacological properties. Benzothiazole is …

Novel 3-Nitro-1H-1,2,4-triazole-Based Amides and Sulfonamides as Potential Antitrypanosomal Agents

MV Papadopoulou, WD Bloomer… - Journal of medicinal …, 2012 - ACS Publications
A series of novel 3-nitro-1 H-1, 2, 4-triazole-based (and in some cases 2-nitro-1 H-imidazole-
based) amides and sulfonamides were characterized for their in vitro antitrypanosomal and …

Current perspective of synthesis of medicinally relevant benzothiazole based molecules: Potential for antimicrobial and anti-inflammatory activities

K Gupta, AK Sirbaiya, V Kumar… - Mini Reviews in …, 2022 - ingentaconnect.com
The therapeutic potential of the majority of the marketed drugs is due to the presence of a
heterocyclic nucleus, which constitutes a huge role in the field of medicinal chemistry. These …

Design, synthesis, and anticancer activity of novel benzothiazole analogues

AY Hassan, MT Sarg… - Journal of Heterocyclic …, 2019 - Wiley Online Library
On the pharmaceutical account of the reported anticancer activity of benzothiazole
derivatives, differently substituted benzothiazole derivatives 2a–c to 34a, b, attached at 2 …

Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues

AA Siddiqui, S Partap, S Khisal, MS Yar, R Mishra - Bioorganic Chemistry, 2020 - Elsevier
Pyridazinone analogues have been known to be potential candidates for anticonvulsant
agents. We have identified several pyridazinone-based anticonvulsant agents. As a …

[HTML][HTML] Design, Synthesis and Biological Activities of (Thio) Urea Benzothiazole Derivatives

JE Mendieta-Wejebe, MC Rosales-Hernández… - International Journal of …, 2023 - mdpi.com
(Thio) ureas ((T) Us) and benzothiazoles (BTs) each have demonstrated to have a great
variety of biological activities. When these groups come together, the 2-(thio) …

Recent insights on synthetic methods and pharmacological potential in relation with structure of benzothiazoles

RK Yadav, R Kumar, H Singh, A Mazumdar… - Medicinal …, 2023 - benthamdirect.com
Benzothiazole is a bicyclic heterocyclic compound that contains benzene fused with 1, 3-
thiazole ring. Several researches established the potential of benzothiazoles as important …