Tunnels for protein export from the endoplasmic reticulum
I Raote, V Malhotra - Annual review of biochemistry, 2021 - annualreviews.org
The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …
A tango for coats and membranes: New insights into ER-to-Golgi traffic
M Aridor - Cell reports, 2022 - cell.com
The realization that the meticulous organization of cellular organelles is not required for the
reconstitution of select intracellular traffic steps has revolutionized cell biology. It transformed …
reconstitution of select intracellular traffic steps has revolutionized cell biology. It transformed …
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress
Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or
impairing β cell function. Understanding the genetic basis of rare diabetes subtypes …
impairing β cell function. Understanding the genetic basis of rare diabetes subtypes …
Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice
Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia,
hyperinsulinemia, and insulin resistance (IR). During the early phase of T2D, insulin …
hyperinsulinemia, and insulin resistance (IR). During the early phase of T2D, insulin …
TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes
I Raote, M Ortega-Bellido, AJM Santos, O Foresti… - Elife, 2018 - elifesciences.org
Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and
retrograde fusion of ERGIC membranes. How do these components come together to …
retrograde fusion of ERGIC membranes. How do these components come together to …
WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells
L Wang, H Liu, X Zhang, E Song, Y Wang, T Xu… - Nature …, 2021 - nature.com
The sorting of soluble secretory proteins from the endoplasmic reticulum (ER) to the Golgi
complex is mediated by coat protein complex II (COPII) vesicles and thought to required …
complex is mediated by coat protein complex II (COPII) vesicles and thought to required …
Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon
The peptide hormone glucagon is a fundamental metabolic regulator that is also being
considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this …
considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this …
Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion
The transport and Golgi organization 1 (TANGO1) proteins play pivotal roles in the secretory
pathway. Full length TANGO1 is a transmembrane protein localised at endoplasmic …
pathway. Full length TANGO1 is a transmembrane protein localised at endoplasmic …
[HTML][HTML] TANGO1 marshals the early secretory pathway for cargo export
TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that
cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of …
cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of …
Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells
Insulin is an essential peptide hormone that maintains blood glucose levels. Although the
mechanisms underlying insulin exocytosis have been investigated, the mechanism of …
mechanisms underlying insulin exocytosis have been investigated, the mechanism of …