A number of machine learning (ML)-based algorithms have been proposed for predicting
mutation-induced stability changes in proteins. In this critical review, we used hypothetical …

Protein interactions play an important role in the discovery of protein functions and pathways
in biological processes. This is especially true in case of the diseases caused by the loss of …

Transcription activation factors and multisubunit coactivator complexes get recruited at
specific chromatin sites via protein domains that recognize histone modifications. Single …

Background Glycoside hydrolases (GH) targeting cellulose, xylan, and chitin are common in
the bacterial genomes that have been sequenced. Little is known, however, about the …

Small heat-shock proteins (sHsps), such as αB-crystallin, are one of the major classes of
molecular chaperone proteins. In vivo, under conditions of cellular stress, sHsps are the …

Viruses encode transcriptional regulatory proteins critical for controlling viral and host gene
expression. Given their multifunctional nature and high sequence divergence, it is unclear …

Protein domains that emerged more recently in evolution have a higher structural disorder
and greater clustering of hydrophobic residues along the primary sequence. It is hard to …

Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix
metalloproteinases (MMPs), enzymes that contribute to cancer and many inflammatory and …

Many bacteria cycle between sessile and motile forms in which they must sense and
respond to internal and external signals to coordinate appropriate physiology. Maintaining …

RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs),
which provide these proteins with a modular architecture. Accumulating evidence supports …