Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair
MK Chen, TR Guilarte - Pharmacology & therapeutics, 2008 - Elsevier
For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …
Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers
F Chauveau, H Boutin, N Van Camp, F Dollé… - European journal of …, 2008 - Springer
Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory
reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug …
reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug …
The 18 kDa translocator protein, microglia and neuroinflammation
GJ Liu, RJ Middleton, CR Hatty, WWY Kam… - Brain …, 2014 - Wiley Online Library
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation
F Chauveau, N Van Camp, F Dollé… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Overexpression of the translocator protein, TSPO (18 kDa), formerly known as the peripheral
benzodiazepine receptor, is a hallmark of activation of cells of monocytic lineage (microglia …
benzodiazepine receptor, is a hallmark of activation of cells of monocytic lineage (microglia …
Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180
AM Dickens, S Vainio, P Marjamäki… - Journal of Nuclear …, 2014 - Soc Nuclear Med
It remains unclear how different translocator protein (TSPO) ligands reflect the spatial extent
of astrocyte or microglial activation in various neuroinflammatory conditions. Here, we use a …
of astrocyte or microglial activation in various neuroinflammatory conditions. Here, we use a …
Recent progress in the development of TSPO PET ligands for neuroinflammation imaging in neurological diseases
MM Alam, J Lee, SY Lee - Nuclear medicine and molecular imaging, 2017 - Springer
Neuroinflammation is heavily associated with various neurological diseases including
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …
TSPO: an evolutionarily conserved protein with elusive functions
F Bonsack, S Sukumari-Ramesh - International journal of molecular …, 2018 - mdpi.com
TSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral
tissue binding sites for benzodiazepines, and was formerly called the peripheral …
tissue binding sites for benzodiazepines, and was formerly called the peripheral …
18F-Radiolabeled Translocator Protein (TSPO) PET Tracers: Recent Development of TSPO Radioligands and Their Application to PET Study
Translocator protein 18 kDa (TSPO) is a transmembrane protein in the mitochondrial
membrane, which has been identified as a peripheral benzodiazepine receptor. TSPO is …
membrane, which has been identified as a peripheral benzodiazepine receptor. TSPO is …
[HTML][HTML] Novel PET imaging of inflammatory targets and cells for the diagnosis and monitoring of giant cell arteritis and polymyalgia rheumatica
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing
Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …
169-amino-acid protein which localizes on the contact sites between the outer and inner …