Molecular targets for Chagas disease: Validation, challenges and lead compounds for widely exploited targets
M Laureano de Souza, TJWJD Lapierre… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Chagas disease (CD) imposes social and economic burdens, yet the available
treatments have limited efficacy in the disease's chronic phase and cause serious adverse …
treatments have limited efficacy in the disease's chronic phase and cause serious adverse …
Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors
E Barbosa da Silva, DA Rocha, IS Fortes… - Journal of Medicinal …, 2021 - ACS Publications
The cysteine proteases, cruzain and Tbr CATL (rhodesain), are therapeutic targets for
Chagas disease and Human African Trypanosomiasis, respectively. Among the known …
Chagas disease and Human African Trypanosomiasis, respectively. Among the known …
From rational design to serendipity: discovery of novel thiosemicarbazones as potent trypanocidal compounds
Chagas disease is a major public health problem caused by Trypanosoma cruzi, with an
estimated 6–7 million people infected and 70 million at risk of infection. T. brucei gambiense …
estimated 6–7 million people infected and 70 million at risk of infection. T. brucei gambiense …
Screening the Pathogen Box to Discover and Characterize New Cruzain and TbrCatL Inhibitors
T do Valle Moreira, LC Martins, LA Diniz… - Pathogens, 2023 - mdpi.com
Chagas disease and Human African Trypanosomiasis, caused by Trypanosoma cruzi and T.
brucei, respectively, pose relevant health challenges throughout the world, placing 65 to 70 …
brucei, respectively, pose relevant health challenges throughout the world, placing 65 to 70 …
Experimental and computational study of aryl-thiosemicarbazones inhibiting cruzain reveals reversible inhibition and a stepwise mechanism
LC Martins, RB de Oliveira, J Lameira… - Journal of Chemical …, 2023 - ACS Publications
Trypanosoma cruzi is a parasite that infects about 6–7 million people worldwide, mostly in
Latin America, causing Chagas disease. Cruzain, the main cysteine protease of T. cruzi, is a …
Latin America, causing Chagas disease. Cruzain, the main cysteine protease of T. cruzi, is a …
Structure‐Activity Relationships, Tolerability and Efficacy of Microtubule‐Active 1,2,4‐Triazolo[1,5‐a]pyrimidines as Potential Candidates to Treat Human African …
Tubulin and microtubules (MTs) are potential protein targets to treat parasitic infections and
our previous studies have shown that the triazolopyrimidine (TPD) class of MT‐active …
our previous studies have shown that the triazolopyrimidine (TPD) class of MT‐active …
The Kavaratamides: Discovery of Linear Lipodepsipeptides from the Marine Cyanobacterium Moorena bouillonii Using a Comparative Chemogeographic Analysis
Kavaratamide A (1), a new linear lipodepsipeptide possessing an unusual isopropyl-O-
methylpyrrolinone moiety, was discovered from the tropical marine filamentous …
methylpyrrolinone moiety, was discovered from the tropical marine filamentous …
Gallic acid alkyl esters: Trypanocidal and Leishmanicidal activity, and target identification via modeling studies
D Steverding, LG do Nascimento, Y Perez-Castillo… - Molecules, 2022 - mdpi.com
Eight gallic acid alkyl esters (1–8) were synthesized via Fischer esterification and evaluated
for their trypanocidal and leishmanicidal activity using bloodstream forms of Trypanosoma …
for their trypanocidal and leishmanicidal activity using bloodstream forms of Trypanosoma …
[HTML][HTML] Development of subunit selective proteasome substrates for Schistosoma species
Schistosomiasis, or bilharzia, is a neglected tropical disease caused by Schistosoma spp.
blood flukes that infects over 200 million people worldwide. Just one partially effective drug …
blood flukes that infects over 200 million people worldwide. Just one partially effective drug …