In mammalian cells, signalling pathways orchestrate cellular growth, differentiation and
survival, as well as many other processes that are essential for the proper functioning of …

Synthetic Notch (synNotch) receptors are genetically encoded, modular synthetic receptors
that enable mammalian cells to detect environmental signals and respond by activating user …

The Notch signaling pathway has fundamental roles in embryonic development and in the
nervous system. The current model of receptor activation involves initiation via a force …

A major goal in synthetic development is to build gene regulatory circuits that control
patterning. In natural development, an interplay between mechanical and chemical …

The Notch signaling pathway is a highly conserved, fundamental process to embryogenesis
and neurogenesis. While force-induced conformational change is known to activate Notch …

Synthetic Notch (synNotch) receptors are modular synthetic components that are genetically
engineered into mammalian cells to detect signals presented by neighboring cells and …

Mammalian Notch signaling occurs when the binding of Delta or Jagged to Notch stimulates
the proteolytic release of the Notch intracellular domain (NICD), which enters the nucleus to …

The execution of a Notch signal at the plasma membrane relies on the mechanical force
exerted onto Notch by its ligand. It has been appreciated that the DSL ligands need to …

A major aim in the field of synthetic biology is developing tools capable of responding to
user-defined inputs by activating therapeutically relevant cellular functions. Gene …

CAR-T cell therapies have been successful in treating numerous hematologic malignancies
as the T cell can be engineered to target a specific antigen associated with the disease …