[HTML][HTML] Gut microbiota, macrophages and diet: an intriguing new triangle in intestinal fibrosis

A Amamou, C O'mahony, M Leboutte, G Savoye… - Microorganisms, 2022 - mdpi.com
Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD) without
specific treatment. As macrophages are the key actors in inflammatory responses and the …

[HTML][HTML] Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis

X Sun, JS Seidman, P Zhao, TD Troutman, NJ Spann… - Cell metabolism, 2020 - cell.com
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory
and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown …

[HTML][HTML] E-cadherin on epithelial–mesenchymal transition in thyroid cancer

X Zhu, X Wang, Y Gong, J Deng - Cancer Cell International, 2021 - Springer
Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck.
Recurrence, metastasis and high malignant expression after routine treatment are serious …

[HTML][HTML] From liver fibrosis to hepatocarcinogenesis: Role of excessive liver H2O2 and targeting nanotherapeutics

M Shao, Y Wang, H Dong, L Wang, X Zhang, X Han… - Bioactive Materials, 2023 - Elsevier
Liver fibrosis and hepatocellular carcinoma (HCC) have been worldwide threats nowadays.
Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic …

TIM‐4 interference in Kupffer cells against CCL4‐induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway

H Wu, G Chen, J Wang, M Deng, F Yuan… - Cell …, 2020 - Wiley Online Library
Objectives T‐cell immunoglobulin domain and mucin domain‐4 (TIM‐4) is selectively
expressed on antigen‐presenting cells (APCs) and modulates various immune responses …

[HTML][HTML] A role for intestinal alkaline phosphatase in preventing liver fibrosis

Y Liu, PM Cavallaro, BM Kim, T Liu, H Wang, F Kühn… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Liver fibrosis is frequently associated with gut barrier dysfunction, and the
lipopolysaccharides (LPS)-TLR4 pathway is common to the development of both. Intestinal …

TGF‐β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro

Q Zhang, X Chang, H Wang, Y Liu… - Environmental …, 2020 - Wiley Online Library
Abstract Nickel oxide nanoparticles (Nano NiO) bears hepatotoxicity, while whether it leads
to liver fibrosis remains unclear. The aim of this study was to establish the Nano NiO …

Aloin Attenuates Oxidative Stress, Inflammation, and CCl4-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling

J Bai, B Qian, T Cai, Y Chen, T Li… - Journal of Agricultural …, 2023 - ACS Publications
Liver fibrosis refers to the excessive buildup of extracellular matrix (ECM) components in
liver tissue. It is considered a pathological response to liver damage for which there is no …

Molecular fingerprint for terminal abdominal aortic aneurysm disease

G Gäbel, BH Northoff, I Weinzierl, S Ludwig… - Journal of the …, 2017 - Am Heart Assoc
Background Clinical decision making in abdominal aortic aneurysms (AAA) relies
completely on diameter. At this point, improved decision tools remain an unmet medical …

[HTML][HTML] Resolvin D1 attenuates CCl4 Induced Liver Fibrosis by Inhibiting Autophagy-Mediated HSC activation via AKT/mTOR Pathway

J Li, X Deng, S Wang, Q Jiang, K Xu - Frontiers in Pharmacology, 2021 - frontiersin.org
Resolvin D1 (RvD1) was previously reported to relieve inflammation and liver damage in
several liver diseases, but its potential role in liver fibrosis remains elusive. The aim of our …