Toxicity of Nano-Titanium Dioxide (TiO2-NP) Through Various Routes of Exposure: a Review

M Shakeel, F Jabeen, S Shabbir, MS Asghar… - Biological trace element …, 2016 - Springer
Abstract Nano-titanium dioxide (TiO 2) is one of the most commonly used materials being
synthesized for use as one of the top five nanoparticles. Due to the extensive application of …

Adverse outcome pathways associated with the ingestion of titanium dioxide nanoparticles—a systematic review

D Rolo, R Assunção, C Ventura, P Alvito, L Gonçalves… - Nanomaterials, 2022 - mdpi.com
Titanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed
through food (E171), cosmetics (eg, toothpaste), and pharmaceuticals. The oral and …

Safety assessment of titanium dioxide (E171) as a food additive

EFSA Panel on Food Additives and Flavourings … - Efsa …, 2021 - Wiley Online Library
The present opinion deals with an updated safety assessment of the food additive titanium
dioxide (E 171) based on new relevant scientific evidence considered by the Panel to be …

NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study

E Abbasi-Oshaghi, F Mirzaei… - International journal of …, 2019 - Taylor & Francis
Purpose This study evaluated the effects of titanium dioxide nanoparticles (TiO2 NPs) on
liver and intestine of normal rats. Methods Male rats were divided into four groups as follows …

Exposure Route of TiO2 NPs from Industrial Applications to Wastewater Treatment and Their Impacts on the Agro-Environment

Z Zahra, Z Habib, S Chung, MA Badshah - Nanomaterials, 2020 - mdpi.com
The tremendous increase in the production and consumption of titanium dioxide (TiO2)
nanoparticles (NPs) in numerous industrial products and applications has augmented the …

In vitro toxicity assessment of zinc and nickel ferrite nanoparticles in human erythrocytes and peripheral blood mononuclear cell

NL Martínez-Rodríguez, S Tavárez… - Toxicology In Vitro, 2019 - Elsevier
Ferrite nanoparticles (NPs) have gained attention in biomedicine due to their many potential
applications, such as targeted drug delivery, their use as contrast agents for magnetic …

Evaluation of distribution, redox parameters, and genotoxicity in Wistar rats co-exposed to silver and titanium dioxide nanoparticles

AC Martins Jr, LF Azevedo… - Journal of Toxicology …, 2017 - Taylor & Francis
The increasing production of silver nanoparticles (AgNPs) and titanium dioxide
nanoparticles (TiO2NPs) has resulted in their elevated concentrations in the environment …

Subchronic oral toxicity study of food-related titanium dioxide nanoparticles in rats involved in Ti biodistribution and gut microbiota

H Lin, J Tan, J Wang, C Xie, B Chen… - Journal of agricultural …, 2023 - ACS Publications
The widespread use of titanium dioxide nanoparticles (TiO2 NPs) in the food industry has
brought about human safety risks related to nanotoxicity. In this study, food-related TiO2 NPs …

Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats

J Akagi, Y Mizuta, H Akane, T Toyoda… - Particle and Fibre …, 2023 - Springer
Abstract Background Though titanium dioxide (TiO2) is generally considered to have a low
impact in the human body, the safety of TiO2 containing nanosized particles (NPs) has …

Hepatoprotective effect of thymol against subchronic toxicity of titanium dioxide nanoparticles: biochemical and histological evidences

A Jafari, Y Rasmi, M Hajaghazadeh… - Environmental Toxicology …, 2018 - Elsevier
The study was aimed to investigate the protective action of thymol against nano titanium
dioxide (nano-TiO 2) induced hepatotoxicity in rats. To achieve this purpose, the rats were …