The therapeutic potential of poly (ADP-ribose) polymerase inhibitors
Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …
[HTML][HTML] Hyperglycemic stress and carbon stress in diabetic glucotoxicity
X Luo, J Wu, S Jing, LJ Yan - Aging and disease, 2016 - ncbi.nlm.nih.gov
Diabetes and its complications are caused by chronic glucotoxicity driven by persistent
hyperglycemia. In this article, we review the mechanisms of diabetic glucotoxicity by …
hyperglycemia. In this article, we review the mechanisms of diabetic glucotoxicity by …
Direct effect of Taxol on free radical formation and mitochondrial permeability transition
G Varbiro, B Veres, F Gallyas Jr, B Sumegi - Free Radical Biology and …, 2001 - Elsevier
To elucidate the potential role of mitochondria in Taxol-induced cytotoxicity, we studied its
direct mitochondrial effects. In Percoll-gradient purified liver mitochondria, Taxol induced …
direct mitochondrial effects. In Percoll-gradient purified liver mitochondria, Taxol induced …
The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice
Microcystin-LR (MC-LR) produced by cyanobacteria in diverse water systems is a potent
specific hepatotoxin and has been documented to induce hepatocyte apoptosis and liver …
specific hepatotoxin and has been documented to induce hepatocyte apoptosis and liver …
Poly (ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications
Poly (ADP-ribose) polymerases (PARPs) are a family of cell signaling enzymes present in
eukaryotes, which are involved in the poly (ADP-ribosylation) of DNA binding proteins. While …
eukaryotes, which are involved in the poly (ADP-ribosylation) of DNA binding proteins. While …
Effect of poly (ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart …
Ischemia-reperfusion induces reactive oxygen species (ROS) formation, and ROS lead to
cardiac dysfunction, in part, via the activation of the nuclear poly (ADP-ribose) polymerase …
cardiac dysfunction, in part, via the activation of the nuclear poly (ADP-ribose) polymerase …
Clinical implications of apoptosis in ischemic myocardium
TM Scarabelli, R Knight, A Stephanou… - Current problems in …, 2006 - Elsevier
Apoptosis, a genetically programmed form of cell death, contributes to myocyte cell loss in a
variety of cardiac pathologies, including cardiac failure and those related to …
variety of cardiac pathologies, including cardiac failure and those related to …
Protein modifications as manifestations of hyperglycemic glucotoxicity in diabetes and its complications
Diabetes and its complications are hyperglycemic toxicity diseases. Many metabolic
pathways in this array of diseases become aberrant, which is accompanied with a variety of …
pathways in this array of diseases become aberrant, which is accompanied with a variety of …
Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress: a new mechanism for the cytoplasmic effect of PARP-1 activation
Previously, it was suggested that the release of nuclearly formed ADP-ribose polymers or
ADP-ribosylated proteins could be responsible for the cytosolic and mitochondrial effects of …
ADP-ribosylated proteins could be responsible for the cytosolic and mitochondrial effects of …
Prevention of doxorubicin-induced acute cardiotoxicity by an experimental antioxidant compound
Doxorubicin is a widely used anticancer agent, but its application is restricted by its
cardiotoxic side effects. The current theory of its cardiotoxicity is based on free radical …
cardiotoxic side effects. The current theory of its cardiotoxicity is based on free radical …