Continuous twin screw wet granulation is one of the key continuous manufacturing
technologies that have gained significant interest in the pharmaceutical industry as well as …

Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical
manufacturing and a potential alternative method to batch granulation processes. It has …

The aim of the study was to compare continuous twin-screw granulation (TSG) with batch-
wise high-shear granulation (HSG). Two different formulations containing either …

Comprehensive understanding of an integrated continuous pharmaceutical technology was
achieved in this study by a combining design of experiments and mechanistic modeling …

The present paper serves as a demonstration how an in-line PAT tool can be used for rapid
and efficient process development in a fully continuous powder to granule line consisting of …

Twin-screw wet granulation offers the possibility to granulate continuously. A drying step
after wet granulation is required to realize a full continuous manufacturing line. Aim of this …

Granule structure has a key influence on tablet critical quality attributes. The ability to control
this structure through excipient choice is an important part of formulation development …

The drying capacity of a continuous vibrated fluid bed dryer was studied using a DoE by
varying microcrystalline cellulose content in the formulation, water amount in the twin-screw …

This paper describes the specific control strategy of the commercial manufacturing process
of an immediate release tablet formulation based on continuous twin-screw wet granulation …

Continuous mixed-suspension mixed-product removal crystallizer cascades are robust and
proven options for continuous manufacturing. However, when applied to a late-stage drug …