The neuro-endocrinological role of microbial glutamate and GABA signaling

R Mazzoli, E Pessione - Frontiers in microbiology, 2016 - frontiersin.org
Gut microbiota provides the host with multiple functions (eg, by contributing to food
digestion, vitamin supplementation, and defense against pathogenic strains) and interacts …

Irritable bowel syndrome, the microbiota and the gut-brain axis

H Raskov, J Burcharth, HC Pommergaard… - Gut …, 2016 - Taylor & Francis
Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now
evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota …

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression

D Huang, Y Wang, JW Thompson, T Yin… - Nature cell …, 2022 - nature.com
Many cancers have an unusual dependence on glutamine. However, most previous studies
have focused on the contribution of glutamine to metabolic building blocks and the energy …

The interneuron energy hypothesis: implications for brain disease

O Kann - Neurobiology of disease, 2016 - Elsevier
Fast-spiking, inhibitory interneurons–prototype is the parvalbumin-positive (PV+) basket cell–
generate action potentials at high frequency and synchronize the activity of numerous …

Neurotransmitter dysfunction in irritable bowel syndrome: emerging approaches for management

M Gros, B Gros, JE Mesonero, E Latorre - Journal of clinical medicine, 2021 - mdpi.com
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is
still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is …

Highly energized inhibitory interneurons are a central element for information processing in cortical networks

O Kann, IE Papageorgiou… - Journal of Cerebral …, 2014 - journals.sagepub.com
Gamma oscillations (~ 30 to 100 Hz) provide a fundamental mechanism of information
processing during sensory perception, motor behavior, and memory formation by …

GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies

JC de Jonge, CH Vinkers, HE Hulshoff Pol… - Frontiers in …, 2017 - frontiersin.org
Schizophrenia is a psychiatric disorder characterized by hallucinations, delusions,
disorganized thinking, and impairments in cognitive functioning. Evidence from postmortem …

Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

G Deidda, IF Bozarth, L Cancedda - Frontiers in cellular neuroscience, 2014 - frontiersin.org
During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …

Consensus paper: neuroimmune mechanisms of cerebellar ataxias

H Mitoma, K Adhikari, D Aeschlimann… - The Cerebellum, 2016 - Springer
In the last few years, a lot of publications suggested that disabling cerebellar ataxias may
develop through immune-mediated mechanisms. In this consensus paper, we discuss the …

Zebrafish as a systems toxicology model for developmental neurotoxicity testing

Y Nishimura, S Murakami, Y Ashikawa… - Congenital …, 2015 - Wiley Online Library
The developing brain is extremely sensitive to many chemicals. Exposure to neurotoxicants
during development has been implicated in various neuropsychiatric and neurological …