Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation
process in which they gradually acquire T-cell characteristics while shedding their legacy of …

T and B cells share a common somatic gene rearrangement mechanism for assembling the
genes that code for their antigen receptors; they also have developmental pathways with …

Macrophages are the principal immune cells of the epididymis and testis, but their origins,
heterogeneity, development, and maintenance are not well understood. Here, we describe …

Ontogenesis of T cells in the thymus is a complex process whose molecular control is poorly
understood. The present study investigated microRNAs involved in human thymocyte …

Precise control of hematopoietic stem cell (HSC) proliferation and differentiation is needed
to maintain a lifetime supply of blood cells. Using genome-wide ENU mutagenesis and …

T lymphocytes, which are central players in orchestrating immune responses, consist of
several subtypes with distinct functions. The thymus is an organ where hematopoietic …

The C-Myb transcription factor is essential for hematopoiesis, including in the T-cell lineage.
The C-Myb locus is a common site of retroviral insertional mutagenesis, however no …

The rate at which cells enter the T cell pathway depends not only on the immigration of
hematopoietic precursors into the strong Notch signaling environment of the thymus but also …

GATA family transcription factors play multiple vital roles in hematopoiesis in many cell
lineages, and in particular, T cells require GATA‐3 for execution of several developmental …

The c-myb proto-oncogene encodes an obligate hematopoietic cell transcription factor
important for lineage commitment, proliferation, and differentiation. Given its critical …