Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

G Ganguly, S Chakrabarti, U Chatterjee… - Drug design …, 2017 - Taylor & Francis
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases
of the elderly people that have devastating effects in terms of morbidity and mortality. The …

Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation

M Jazvinšćak Jembrek, PR Hof… - Oxidative medicine and …, 2015 - Wiley Online Library
Alzheimer's disease (AD), the most common chronic and progressive neurodegenerative
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …

Oxidative stress, neuroinflammation, and NADPH oxidase: implications in the pathogenesis and treatment of Alzheimer's disease

U Ganguly, U Kaur, SS Chakrabarti… - Oxidative Medicine …, 2021 - Wiley Online Library
NADPH oxidase as an important source of intracellular reactive oxygen species (ROS) has
gained enormous importance over the years, and the detailed structures of all the …

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

M Chattopadhyay, VK Khemka, G Chatterjee… - Molecular and cellular …, 2015 - Springer
Oxidative stress in the insulin target tissues has been implicated in the pathophysiology of
type 2 diabetes. The study has examined the oxidative stress parameters in the …

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

M Pennisi, R Crupi, R Di Paola… - Journal of …, 2017 - Wiley Online Library
Alzheimer disease (AD) is a progressive neurodegenerative disorder leading to cognitive
decline, neuropsychiatric symptoms, disability, caregiver burden, and premature death. It …

[HTML][HTML] Metabolic risk factors of sporadic Alzheimer's disease: implications in the pathology, pathogenesis and treatment

S Chakrabarti, VK Khemka, A Banerjee… - Aging and …, 2015 - ncbi.nlm.nih.gov
Abstract Alzheimer's disease (AD), the major cause of dementia among the elderly world-
wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority …

[HTML][HTML] Neuroprotective effect of caffeic acid phenethyl ester in a mouse model of Alzheimer's disease involves Nrf2/HO-1 pathway

F Morroni, G Sita, A Graziosi, E Turrini… - Aging and …, 2018 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually
worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in …

Islet amyloid polypeptide: a partner in crime with Aβ in the pathology of alzheimer's disease

AF Raimundo, S Ferreira, IC Martins… - Frontiers in molecular …, 2020 - frontiersin.org
Diabetes affects hundreds of millions of patients worldwide. Despite the advances in
understanding the disease and therapeutic options, it remains a leading cause of death and …

Inhibition of IAPP aggregation and toxicity by natural products and derivatives

A Pithadia, JR Brender, CA Fierke… - Journal of diabetes …, 2016 - Wiley Online Library
Fibrillar aggregates of human islet amyloid polypeptide, hIAPP, a pathological feature seen
in some diabetes patients, are a likely causative agent for pancreatic beta‐cell toxicity …

Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity

MG Prado Lima, HL Schimidt… - Proceedings of the …, 2018 - National Acad Sciences
Recently, nongenetic animal models to study the onset and development of Alzheimer's
disease (AD) have appeared, such as the intrahippocampal infusion of peptides present in …