Gene environment interactions in the etiology of neural tube defects
RH Finnell, CD Caiaffa, SE Kim, Y Lei, J Steele… - Frontiers in …, 2021 - frontiersin.org
Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …
United States. Estimates from the United States Center for Disease Control and Prevention …
Progress report on new antiepileptic drugs: a summary of the Twelfth Eilat Conference (EILAT XII)
M Bialer, SI Johannessen, RH Levy, E Perucca… - Epilepsy research, 2015 - Elsevier
Summary The Twelfth Eilat Conference on New Antiepileptic Drugs (AEDs)–EILAT XII, took
place in Madrid, Spain from August 31st to September 3rd 2014. About 130 basic scientists …
place in Madrid, Spain from August 31st to September 3rd 2014. About 130 basic scientists …
Insights into structural modifications of valproic acid and their pharmacological profile
Valproic acid (VPA) is a well-established anticonvulsant drug discovered serendipitously
and marketed for the treatment of epilepsy, migraine, bipolar disorder and neuropathic pain …
and marketed for the treatment of epilepsy, migraine, bipolar disorder and neuropathic pain …
Progress report on new antiepileptic drugs: a summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII)
M Bialer, SI Johannessen, RH Levy, E Perucca… - …, 2017 - Wiley Online Library
Summary The Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT
XIII) took place in Madrid, Spain, on June 26–29, 2016, and was attended by> 200 …
XIII) took place in Madrid, Spain, on June 26–29, 2016, and was attended by> 200 …
Chirality as an important factor for the development of new antiepileptic drugs
M Abram, M Jakubiec, K Kamiński - ChemMedChem, 2019 - Wiley Online Library
In recent years, chiral molecules (especially enantiomers) have occupied a significant place
in pharmaceutical industry and have played a prominent role in the development of new …
in pharmaceutical industry and have played a prominent role in the development of new …
Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical …
M Bialer, SI Johannessen, MJ Koepp, RH Levy… - …, 2020 - Wiley Online Library
Abstract Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the
epilepsy community to appraise the latest data on new antiepileptic drugs and emergency …
epilepsy community to appraise the latest data on new antiepileptic drugs and emergency …
Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain
N Erenburg, R Hamed, C Shaul, E Perucca… - Epilepsia, 2023 - Wiley Online Library
Objectives To investigate the comparative antiseizure activity of the individual enantiomers
of fenfluramine and its major active primary metabolite norfenfluramine in rodent seizure …
of fenfluramine and its major active primary metabolite norfenfluramine in rodent seizure …
Comparative efficacy of valnoctamide and sec‐butylpropylacetamide (SPD) in terminating nerve agent–induced seizures in pediatric rats
Objectives Children and adults are likely to be among the casualties in a civilian nerve agent
exposure. This study evaluated the efficacy of valnoctamide (racemic‐VCD), sec …
exposure. This study evaluated the efficacy of valnoctamide (racemic‐VCD), sec …
sec‐Butyl‐propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon‐induced status epilepticus in rats
G Bar‐Klein, E Swissa, L Kamintsky… - …, 2014 - Wiley Online Library
Summary Objective Organophosphates (OPs) are commonly used insecticides for
agriculture and domestic purposes, but may also serve as nerve agents. Exposure to OPs …
agriculture and domestic purposes, but may also serve as nerve agents. Exposure to OPs …
Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS‐active derivative of valproic acid with low teratogenic potential
T Shekh‐Ahmad, N Hen, B Yagen, JH McDonough… - …, 2014 - Wiley Online Library
Objective Valnoctamide (VCD), a central nervous system (CNS)–active chiral constitutional
isomer of valpromide, the corresponding amide of valproic acid (VPA), is currently …
isomer of valpromide, the corresponding amide of valproic acid (VPA), is currently …