Peptide macrocycles have found applications that range from drug discovery to
nanomaterials. These ring-shaped molecules have shown remarkable capacity for …

Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

Constricting the peptide backbone into a more defined conformational form through
cyclization is an activity evolved in nature and in synthetic work, the latter straddling only the …

Aromatic oligoamide foldamers possess a high potential for mimicking the secondary
structures of biopolymers. These oligomers are efficiently designed, easy to synthesize, and …

Covering: up to July 2008 Ribosomally synthesized bacterial natural products rival the
nonribosomal peptides in their structural and functional diversity. The last decade has seen …

Activation of the human complement system of plasma proteins during immunological host
defense can result in overproduction of potent proinflammatory peptides such as the …

This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic
fragments in their structure. These motifs are present in many natural products and synthetic …

Peptides are increasingly important drug candidates, offering numerous advantages over
conventional small molecules. However, they face significant challenges related to stability …

Can one join both ends of a helix? A helical aromatic oligoamide was macrocyclized into a
saddle-shaped bifunctional clip molecule that self-assembles into discrete circular …

The synthesis, structure, and physical properties of macrocycles have fascinated chemists
for many years. Their inherent properties make them useful in areas as diverse as ion …