Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …

Simple Summary Colorectal cancer (CRC) is a heterogeneous disease that can be divided
into 4 consensus molecular subtypes (CMS) according to molecular profiling. The CMS …

The cellular prion protein PrPC partners with caveolin-1 (CAV1) in neurodegenerative
diseases but whether this interplay occurs in cancer has never been investigated. By …

The prion protein is a multifunctional protein that exists in at least two different folding states.
It is subject to diverse proteolytic processing steps that lead to prion protein fragments some …

Human Dental Pulp Stem Cells (hDPSCs) represent a type of adult mesenchymal stem cells
that have the ability to differentiate in vitro in several lineages such as odontoblasts …

Background Comprehensive transcriptomic analyses have shown that colorectal cancer
(CRC) is heterogeneous and have led to the definition of molecular subtypes among which …

Simple Summary The cellular prion protein PrPC is best known for its involvement, under its
pathogenic isoform, in a group of neurodegenerative diseases. Notwithstanding, an …

The cellular prion protein (PrPC) is well-known for its involvement, under its pathogenic
protease-resistant form (PrPSc), in a group of neurodegenerative diseases, known as prion …

The prion protein (PrP) is an enigmatic molecule with a pleiotropic effect on different cell
types; it is localized stably in lipid raft microdomains and it is able to recruit downstream …

The CMS4 mesenchymal subtype of colorectal cancer (CRC) is associated with poor
prognosis and resistance to treatment. The cellular prion protein PrPC is overexpressed in …