Prions and neurodegenerative diseases: a focus on Alzheimer's disease
A Crestini, F Santilli, S Martellucci… - Journal of …, 2022 - content.iospress.com
Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …
YAP/TAZ signalling in colorectal cancer: Lessons from consensus molecular subtypes
S Mouillet-Richard, P Laurent-Puig - Cancers, 2020 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a heterogeneous disease that can be divided
into 4 consensus molecular subtypes (CMS) according to molecular profiling. The CMS …
into 4 consensus molecular subtypes (CMS) according to molecular profiling. The CMS …
A proof of concept for targeting the PrPC - Amyloid β peptide interaction in basal prostate cancer and mesenchymal colon cancer
S Mouillet-Richard, S Martin-Lannerée, D Le Corre… - Oncogene, 2022 - nature.com
The cellular prion protein PrPC partners with caveolin-1 (CAV1) in neurodegenerative
diseases but whether this interplay occurs in cancer has never been investigated. By …
diseases but whether this interplay occurs in cancer has never been investigated. By …
[HTML][HTML] The prion protein and its ligands: Insights into structure-function relationships
The prion protein is a multifunctional protein that exists in at least two different folding states.
It is subject to diverse proteolytic processing steps that lead to prion protein fragments some …
It is subject to diverse proteolytic processing steps that lead to prion protein fragments some …
Cellular and Molecular Mechanisms Mediated by recPrPC Involved in the Neuronal Differentiation Process of Mesenchymal Stem Cells
Human Dental Pulp Stem Cells (hDPSCs) represent a type of adult mesenchymal stem cells
that have the ability to differentiate in vitro in several lineages such as odontoblasts …
that have the ability to differentiate in vitro in several lineages such as odontoblasts …
The cellular prion protein controls the mesenchymal-like molecular subtype and predicts disease outcome in colorectal cancer
D Le Corre, A Ghazi, R Balogoun, C Pilati, T Aparicio… - …, 2019 - thelancet.com
Background Comprehensive transcriptomic analyses have shown that colorectal cancer
(CRC) is heterogeneous and have led to the definition of molecular subtypes among which …
(CRC) is heterogeneous and have led to the definition of molecular subtypes among which …
The cellular prion protein and the hallmarks of cancer
S Mouillet-Richard, A Ghazi, P Laurent-Puig - Cancers, 2021 - mdpi.com
Simple Summary The cellular prion protein PrPC is best known for its involvement, under its
pathogenic isoform, in a group of neurodegenerative diseases. Notwithstanding, an …
pathogenic isoform, in a group of neurodegenerative diseases. Notwithstanding, an …
Emerging roles of the cellular prion protein (PrPC) and 37/67 kDa laminin receptor (RPSA) interaction in cancer biology
A Limone, V Maggisano, D Sarnataro… - Cellular and Molecular …, 2023 - Springer
The cellular prion protein (PrPC) is well-known for its involvement, under its pathogenic
protease-resistant form (PrPSc), in a group of neurodegenerative diseases, known as prion …
protease-resistant form (PrPSc), in a group of neurodegenerative diseases, known as prion …
Prion protein in stem cells: A lipid raft component involved in the cellular differentiation process
S Martellucci, C Santacroce, F Santilli… - International journal of …, 2020 - mdpi.com
The prion protein (PrP) is an enigmatic molecule with a pleiotropic effect on different cell
types; it is localized stably in lipid raft microdomains and it is able to recruit downstream …
types; it is localized stably in lipid raft microdomains and it is able to recruit downstream …
Prognostic value of the PrPC-ILK-IDO1 axis in the mesenchymal colorectal cancer subtype
The CMS4 mesenchymal subtype of colorectal cancer (CRC) is associated with poor
prognosis and resistance to treatment. The cellular prion protein PrPC is overexpressed in …
prognosis and resistance to treatment. The cellular prion protein PrPC is overexpressed in …