Importance Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized
by formation of long chains of hemoglobin when deoxygenated within capillary beds …

Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

This 2020 installment of the annual 'Antibodies to Watch'series documents the antibody
therapeutics approved in 2019 and in regulatory review in the United States or European …

For the past 10 years, the annual 'Antibodies to watch'articles have provided updates on key
events in the late-stage development of antibody therapeutics, such as first regulatory review …

Sickle cell anemia (SCA) was first described in the Western literature more than 100 years
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …

Early diagnosis, treatment, and prevention of a vaso‐occlusive crisis (VOC) are critical to the
management of patients with sickle cell disease. It is essential to differentiate between VOC …

Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Sickle cell disease (SCD) results from a single base pair change in the sixth codon of the β-
globin chain of hemoglobin, which promotes aggregation of deoxyhemoglobin, increasing …

We have explored the fundamental biological processes by which complex carbohydrates
expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell …

Sickle cell disease (SCD) results in chronic hemolytic anemia, recurrent vascular occlusion,
insidious vital organ deterioration, early mortality, and diminished quality of life. Life …