Trauma is the leading cause of death in individuals aged 1 to 45 years, with traumatic brain
injury (TBI) responsible for most these deaths; more than 50,000 deaths per year in the …

Normal haemostasis depends on an intricate balance between mechanisms of bleeding and
mechanisms of thrombosis, and this balance can be altered after traumatic brain injury (TBI) …

BACKGROUND It is becoming a standard practice that any “positive” identification of a
radiographic intracranial injury requires transfer of the patient to a trauma center for …

BACKGROUND Thrombin is the central coagulation protease that activates clotting proteins,
triggers platelet aggregation, and converts fibrinogen to fibrin. Relationships between …

BACKGROUND Coagulopathy is a common complication after severe trauma. The efficacy
of 4-factor prothrombin complex concentrate (4-PCC) as an adjunct to fresh frozen plasma …

BACKGROUND To optimize neurosurgical resources, guidelines were developed at our
institution, allowing the acute care surgeons to independently manage traumatic intracranial …

BACKGROUND Transfusion of balanced ratios of plasma to platelets and red blood cells
has been shown to reduce early death from exsanguination in trauma patients. Aside from …

BACKGROUND Coagulopathy is a major determinant of disability and death in patients with
traumatic intracranial hemorrhage. However, the correlation between coagulopathy defined …

Introduction The development of coagulopathy of trauma is multifactorial associated with
hypoperfusion and consumption of coagulation factors. Previous studies have compared the …

Prothrombin complex concentrate (PCC) is a term to describe pharmacological products that
contain lyophilized, human plasma-derived vitamin K-dependent factors (F), FII, FVII, FIX …