Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse
S DeWolf, Y Elhanati, K Nichols, NR Waters… - Science translational …, 2023 - science.org
T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-
resident T cells at sites of pathology in human organs remains poorly understood. We …
resident T cells at sites of pathology in human organs remains poorly understood. We …
[HTML][HTML] Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease
As a result of impressive increases in our knowledge of rodent and human immunology, the
understanding of the pathophysiologic mechanisms underlying graft-versus-host disease …
understanding of the pathophysiologic mechanisms underlying graft-versus-host disease …
[HTML][HTML] GVHD pathogenesis, prevention and treatment: lessons from humanized mouse transplant models
Graft-vs-host disease (GVHD) is the most common cause of non-relapse mortality following
allogeneic hematopoietic stem cell transplantation (HSCT) despite advances in conditioning …
allogeneic hematopoietic stem cell transplantation (HSCT) despite advances in conditioning …
Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming
I Saha, AS Chawla, APBN Oliveira, EE Elfers… - Proceedings of the …, 2024 - pnas.org
Alloreactive memory T cells have been implicated as central drivers of transplant rejection.
Perplexingly, innate cytokines, such as IL-6, IL-1β, and IL-12, are also associated with …
Perplexingly, innate cytokines, such as IL-6, IL-1β, and IL-12, are also associated with …
[HTML][HTML] Single-cell RNA sequencing reveals the role of immune-related autophagy in spinal cord injury in rats
E Li, R Yan, K Yan, R Zhang, Q Zhang, P Zou… - Frontiers in …, 2022 - frontiersin.org
Spinal cord injury refers to damage to the spinal cord due to trauma, disease, or
degeneration; and the number of new cases is increasing yearly. Significant cellular …
degeneration; and the number of new cases is increasing yearly. Significant cellular …