Chronic hepatitis B virus infection

WK Seto, YR Lo, JM Pawlotsky, MF Yuen - The Lancet, 2018 - thelancet.com
Chronic hepatitis B virus infection is a global public health threat that causes considerable
liver-related morbidity and mortality. It is acquired at birth or later via person-to-person …

[PDF][PDF] Antiviral therapy for chronic hepatitis B viral infection in adults: a systematic review and meta‐analysis

ASF Lok, BJ McMahon, RS Brown Jr, JB Wong… - …, 2016 - Wiley Online Library
Chronic hepatitis B viral (HBV) infection remains a significant global health problem.
Evidence‐based guidelines are needed to help providers determine when treatment should …

Cancer‐associated fibroblast‐mediated cellular crosstalk supports hepatocellular carcinoma progression

M Song, J He, QZ Pan, J Yang, J Zhao, YJ Zhang… - …, 2021 - Wiley Online Library
Background and Aims Cancer‐associated fibroblasts (CAFs) are key players in multicellular,
stromal‐dependent alterations leading to HCC pathogenesis. However, the intricate …

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

P Lampertico, K Agarwal, T Berg, M Buti… - Journal of …, 2017 - Elsevier
Hepatitis B virus (HBV) infection remains a global public health problem with changing
epidemiology due to several factors including vaccination policies and migration. This …

Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update

SK Sarin, M Kumar, GK Lau, Z Abbas, HLY Chan… - Hepatology …, 2016 - Springer
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest
rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection …

High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B

GA Kim, YS Lim, S Han, J Choi, JH Shim, KM Kim… - Gut, 2018 - gut.bmj.com
Objective High serum HBV DNA levels are associated with high risks of hepatocellular
carcinoma (HCC) and cirrhosis in patients with chronic hepatitis B (CHB). Although the …

Guidance on treatment endpoints and study design for clinical trials aiming to achieve cure in chronic hepatitis B and D: Report from the 2022 AASLD-EASL HBV-HDV …

MG Ghany, M Buti, P Lampertico, HM Lee - Hepatology, 2023 - journals.lww.com
Representatives from academia, industry, regulatory agencies, and patient advocacy groups
convened under the American Association for the Study of Liver Diseases (AASLD) and the …

Liraglutide, sitagliptin, and insulin glargine added to metformin: the effect on body weight and intrahepatic lipid in patients with type 2 diabetes mellitus and …

J Yan, B Yao, H Kuang, X Yang, Q Huang, T Hong… - …, 2019 - Wiley Online Library
To investigate the effect of antidiabetic agents on nonalcoholic fatty liver disease (NAFLD) in
patients with type 2 diabetes mellitus (T2DM), 75 patients with T2DM and NAFLD under …

[PDF][PDF] Present and future therapies of hepatitis B: from discovery to cure

TJ Liang, TM Block, BJ McMahon, MG Ghany… - …, 2015 - Wiley Online Library
Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million
people worldwide. While treatment for HBV has improved, HBV patients often require …

Hepatitis B virus: advances in prevention, diagnosis, and therapy

MH Nguyen, G Wong, E Gane, JH Kao… - Clinical microbiology …, 2020 - Am Soc Microbiol
Currently, despite the use of a preventive vaccine for several decades as well as the use of
effective and well-tolerated viral suppressive medications since 1998, approximately 250 …