Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Collagen XVIII is a ubiquitous basement membrane (BM) proteoglycan produced in three
tissue-specific isoforms that differ in their N-terminal non-collagenous sequences, but share …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for
modeling neurological diseases. However, iPSC models are fraught with technical …

The prevalence of Parkinson's disease (PD) is increasing but the development of novel
treatment strategies and therapeutics altering the course of the disease would benefit from …

The incidence of Alzheimer's disease (AD), which is characterized by progressive cognitive
decline that correlates with the spread of tau protein aggregation in the cortical mantle, is …

Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on
the neuronal surface that have been implicated in the control of neuroplasticity and memory …

Aims Although changes in extracellular matrix (ECM) scaffold have been reported previously
in Alzheimer's disease (AD) compared to normal ageing, it is not known how alterations in …

Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPR
ER, which are strongly associated with several diseases and the aging process. We …

Intracortical microelectrodes are a critical component of brain-machine interface (BMI)
systems. The recording performance of intracortical microelectrodes used for both basic …