Prostate cancer is one of the most frequently diagnosed malignancies in developed
countries and approximately 248,530 new cases of prostate cancer are likely to be …

Sex steroid hormones such as estrogens and androgens are involved in the development
and differentiation of the breast tissue. The activity and concentration of sex steroids is …

All aspects of prostate cancer evolution are closely related to androgen levels and the status
of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways …

Sex-steroid hormones have been investigated for decades for their oncogenic properties in
hormone-dependent cancers. The increasing body of knowledge on the biological actions of …

Our understanding of the intracrine (or local) regulation of estrogen and other steroid
synthesis and degradation expanded in the last decades, also thanks to recent …

In general, the risk of being diagnosed with cancer increases with age; however, the
development of estrogen-receptor-positive (ER+) cancer types in women are more closely …

Prostate cancer (PCa) is a major health care problem because of its high prevalence, health‐
related costs, and mortality. Epidemiological studies have suggested an important role of …

Purpose: Prostate cancer is a heterogeneous genetic disease, and molecular methods for
predicting prognosis in patients with aggressive form of the disease are urgently needed to …

The incidence of ovarian cancer has been epidemiologically related to female reproductive
events and hormone replacement therapy after menopause. This highlights the importance …

Background Androgen inactivation occurs mainly through the glucuronidation conjugative
reaction mediated by UDP-glucuronosyltransferases (UGTs). This metabolic process is …