Optical approaches for investigating neuromodulation and G protein–coupled receptor signaling
Despite the fact that roughly 40% of all US Food and Drug Administration (FDA)-approved
pharmacological therapeutics target G protein–coupled receptors (GPCRs), there remains a …
pharmacological therapeutics target G protein–coupled receptors (GPCRs), there remains a …
Get ready to sharpen your tools: A short guide to heterotrimeric G protein activity biosensors
R Janicot, M Garcia-Marcos - Molecular Pharmacology, 2024 - Elsevier
ABSTRACT G protein-coupled receptors (GPCRs) are the largest class of transmembrane
receptors encoded in the human genome, and they initiate cellular responses triggered by a …
receptors encoded in the human genome, and they initiate cellular responses triggered by a …
Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo-and heterodimers
The metabotropic glutamate receptors (mGluRs) are family C, dimeric G protein–coupled
receptors (GPCRs), which play critical roles in synaptic transmission. Despite an increasing …
receptors (GPCRs), which play critical roles in synaptic transmission. Despite an increasing …
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization
A Strauss, AJ Gonzalez-Hernandez, J Lee… - Nature …, 2024 - nature.com
The metabotropic glutamate receptors (mGluRs) are neuromodulatory family CG protein
coupled receptors which assemble as dimers and allosterically couple extracellular ligand …
coupled receptors which assemble as dimers and allosterically couple extracellular ligand …
GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity
S Melgrati, OJ Gerken, M Artinger, E Radice… - Frontiers in …, 2023 - frontiersin.org
Immune responses highly depend on the effective trafficking of immune cells into and within
secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge …
secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge …
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling
G-protein–coupled receptors (GPCRs) compose the largest family of transmembrane
receptors and are targets of approximately one-third of Food and Drug Administration …
receptors and are targets of approximately one-third of Food and Drug Administration …
[HTML][HTML] Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk
Cellular signaling involves a large repertoire of membrane receptors operating in
overlapping spatiotemporal regimes and targeting many common intracellular effectors …
overlapping spatiotemporal regimes and targeting many common intracellular effectors …
Emerging modes of regulation of neuromodulatory G protein-coupled receptors
In the nervous system, G protein-coupled receptors (GPCRs) control neuronal excitability,
synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally …
synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally …
Histamine H1 Receptor-Mediated JNK Phosphorylation Is Regulated by Gq Protein-Dependent but Arrestin-Independent Pathways
S Michinaga, A Nagata, R Ogami, Y Ogawa… - International Journal of …, 2024 - mdpi.com
Arrestins are known to be involved not only in the desensitization and internalization of G
protein-coupled receptors but also in the G protein-independent activation of mitogen …
protein-coupled receptors but also in the G protein-independent activation of mitogen …
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization
The metabotropic glutamate receptors (mGluRs) are neuromodulatory family CG protein
coupled receptors which assemble as dimers and allosterically couple extracellular ligand …
coupled receptors which assemble as dimers and allosterically couple extracellular ligand …