Self-assembled mRNA vaccines
Abstract mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …
Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Perspective on the Martini model
SJ Marrink, DP Tieleman - Chemical Society Reviews, 2013 - pubs.rsc.org
The Martini model, a coarse-grained force field for biomolecular simulations, has found a
broad range of applications since its release a decade ago. Based on a building block …
broad range of applications since its release a decade ago. Based on a building block …
Improved parameters for the martini coarse-grained protein force field
DH De Jong, G Singh, WFD Bennett… - Journal of chemical …, 2013 - ACS Publications
The Martini coarse-grained force field has been successfully used for simulating a wide
range of (bio) molecular systems. Recent progress in our ability to test the model against …
range of (bio) molecular systems. Recent progress in our ability to test the model against …
Going backward: a flexible geometric approach to reverse transformation from coarse grained to atomistic models
TA Wassenaar, K Pluhackova… - Journal of chemical …, 2014 - ACS Publications
The conversion of coarse-grained to atomistic models is an important step in obtaining
insight about atomistic scale processes from coarse-grained simulations. For this process …
insight about atomistic scale processes from coarse-grained simulations. For this process …
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria
M Gohrbandt, A Lipski, JW Grimshaw… - The EMBO …, 2022 - embopress.org
All living organisms adapt their membrane lipid composition in response to changes in their
environment or diet. These conserved membrane‐adaptive processes have been studied …
environment or diet. These conserved membrane‐adaptive processes have been studied …
The power of coarse graining in biomolecular simulations
HI Ingólfsson, CA Lopez, JJ Uusitalo… - Wiley …, 2014 - Wiley Online Library
Computational modeling of biological systems is challenging because of the multitude of
spatial and temporal scales involved. Replacing atomistic detail with lower resolution …
spatial and temporal scales involved. Replacing atomistic detail with lower resolution …
The continuing mystery of lipid rafts
I Levental, SL Veatch - Journal of molecular biology, 2016 - Elsevier
Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …
tremendous amount of attention and interest and nearly as much controversy. The …
[HTML][HTML] Lipid-dependent regulation of the unfolded protein response
Protein folding homeostasis in the lumen of the endoplasmic reticulum is defended by signal
transduction pathways that are activated by an imbalance between unfolded proteins and …
transduction pathways that are activated by an imbalance between unfolded proteins and …