DNA topoisomerases are the targets of important anticancer and antibacterial drugs.
Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines …

DNA topoisomerases I and II (Top1 and Top2) are established molecular targets of
anticancer drugs. 1-5 Mammalian somatic cells express six topoisomerase genes: two TOP1 …

Despite the success of genomics in identifying new essential bacterial genes, there is a lack
of sustainable leads in antibacterial drug discovery to address increasing multidrug …

Topoisomerase II is an essential enzyme that is required for virtually every process that
requires movement of DNA within the nucleus or the opening of the double helix. This …

The extensive length, compaction, and interwound nature of DNA, together with its
controlled and restricted movement in eukaryotic cells, create a number of topological issues …

Type II topoisomerases regulate DNA topology by making a double-stranded break in one
DNA duplex, transporting another DNA segment through this break and then resealing it …

Although quinolones are the most commonly prescribed antibacterials, their use is
threatened by an increasing prevalence of resistance. The most common causes of …

The catalytic steps through which DNA topoisomerases produce their biological effects and
the interference of drug molecules with the enzyme–DNA cleavage complex have been …

RNA represents a prominent class of biomolecules. Present in all living systems, RNA plays
many essential roles in gene expression, regulation, and development. Accordingly, many …

Type II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA
replication, recombination and transcription. They change DNA topology by forming a …