Abstract Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their
roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic …

Adrenal steroidogenesis has, for decades, been depicted as three biosynthesis pathways–
the mineralocorticoid, glucocorticoid and androgen pathways with aldosterone, cortisol and …

The radiation-induced bystander effect (RIBE) is the initiation of biological end points in cells
(bystander cells) that are not directly traversed by an incident-radiation track, but are in close …

In patients with primary aldosteronism, specific treatment provides prognostic benefit over
optimal antihypertensive therapy and is therefore crucial to reduce mortality and morbidity in …

Anabolic androgenic steroids (AAS) are misused very frequently in sport competitions as
performance enhancing agents. One of the doping compounds that has been detected with …

Although cytochrome P450 (CYP) systems including the adrenal ones are being
investigated since many years, there are still reactions and regulation patterns that have …

Genetic polymorphisms in cytochrome P450 (CYP) or UDP-glucuronosyltransferase (UGT)
genes can lead to changes in endocrine regulation or drug metabolism. Based on the …

Abstract Background 21-deoxycortisol (21-DF) is the key intermediate to manufacture
pharmaceutical glucocorticoids. Recently, a Japan patent has realized 21-DF production via …

The cholesterol hydroxylase/lyase (CHL) system, located in the mitochondria of the
mammalian adrenal cortex cells, consists of cytochrome P450scc (CYP11A1), adrenodoxin …

Human cytochrome P450 enzymes (CYPs or P450s) are known to be reduced by their
electron transfer partners in the absence of substrate and in turn to reduce other acceptor …