Laminin, one of the most widely expressed extracellular matrix proteins, exerts many
important functions in multiple organs/systems and at various developmental stages …

Visual impairment and blindness is widespread across the human population, and the
development of therapies for ocular pathologies is of high priority. The zebrafish represents …

Zebrafish embryos and early larvae are becoming increasingly important as models in
biomedical research because of their low cost, high throughput and potential as a …

Cerebellar dysplasia with cysts (CDC) is an imaging finding typically seen in combination
with cobblestone cortex and congenital muscular dystrophy in individuals with …

The Neuromutagenesis Facility at the Jackson Laboratory generated a mouse model of
retinal vasculopathy, nmf223, which is characterized clinically by vitreal fibroplasia and …

Synapses in the outer retina are the first information relay points in vision. Here,
photoreceptors form synapses onto two types of interneurons, bipolar cells and horizontal …

Using high-resolution live imaging in zebrafish, we show that presumptive eye cells acquire
apicobasal polarity and adopt neuroepithelial character prior to other regions of the neural …

Rod and cone photoreceptors possess ribbon synapses that assist in the transmission of
graded light responses to second-order bipolar and horizontal cells of the vertebrate retina …

purpose. In this study recessive zebrafish mutations in the genes encoding laminin β1
(lamb1) and laminin γ1 (lamc1) were used to determine the functions of these laminin …

The zebrafish is one of the leading models for the analysis of the vertebrate visual system. A
wide assortment of molecular, genetic, and cell biological approaches is available to study …