Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the
view of cancer as a tumor cell-centric disease. The tumor microenvironment, especially …

Epigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted
inhibition of Brd4 suppresses growth and induces apoptosis of various cancer cells. In …

We present WhichTF, a computational method to identify functionally important transcription
factors (TFs) from chromatin accessibility measurements. To rank TFs, WhichTF applies an …

CD8+ T cell exhaustion (Tex) limits disease control during chronic viral infections and
cancer. Here, we investigated the epigenetic factors mediating major chromatin-remodeling …

Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the
exhaustion of T cells, and blockade of the PD-1 pathway is an effective immunotherapeutic …

Thirty years of foundational research investigating molecular and cellular mechanisms
promoting T cell exhaustion are now enabling rational design of T cell–based therapies for …

Many acute myeloid leukemia (AML) patients exhibit hallmarks of immune exhaustion, such
as increased myeloid-derived suppressor cells, suppressive regulatory T cells and …

Staphylococcus aureus is a common cause of surgical-site infections, including those
arising after craniotomy, which is performed to access the brain for the treatment of tumors …

Epigenetics involves the study of various modes of adaptable transcriptional regulation,
contributing to cell identity, characteristics, and function. During central nervous system …

Peritoneal macrophages (PMs), which resided in peritoneal cavity, are crucial to maintain
tissue homeostasis and immunity. Macrophage self-renewal and polarization states are …