Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Pyro-phototronic effect: An effective route toward self-powered photodetection

S Sahare, P Ghoderao, MK Sharma, M Solovan… - Nano Energy, 2023 - Elsevier
The Photodetector (PD) refers to an energy harvesting device that can directly convert light
energy into electric current. Such a device has been widely used in different applications …

Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast

R Chen, J Gao, W Yu, X Chen, X Zhai, Y Chen… - Nature Chemical …, 2022 - nature.com
Advances in synthetic biology enable microbial hosts to synthesize valuable natural
products in an efficient, cost-competitive and safe manner. However, current engineering …

Reconstructing organisms in silico: genome-scale models and their emerging applications

X Fang, CJ Lloyd, BO Palsson - Nature Reviews Microbiology, 2020 - nature.com
Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

[HTML][HTML] Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism

J Zhang, SD Petersen, T Radivojevic, A Ramirez… - Nature …, 2020 - nature.com
Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …

Designing microbial cell factories for the production of chemicals

JS Cho, GB Kim, H Eun, CW Moon, SY Lee - Jacs Au, 2022 - ACS Publications
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

[HTML][HTML] De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …

Rhea, the reaction knowledgebase in 2022

P Bansal, A Morgat, KB Axelsen… - Nucleic acids …, 2022 - academic.oup.com
Abstract Rhea (https://www. rhea-db. org) is an expert-curated knowledgebase of
biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of …

An atlas of human metabolism

JL Robinson, P Kocabaş, H Wang, PE Cholley… - Science …, 2020 - science.org
Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and
provide a scaffold for the integrative analysis of omics data. Researchers have developed …

Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …