Statins are members of a class of pharmaceutical widely used to reduce high levels of serum
cholesterol. In addition, statins have so-called “pleiotropic effects,” which include …

Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

B orrelia burgdorferi, the agent of L yme disease, is maintained in nature within an enzootic
cycle involving a mammalian reservoir and an I xodes sp. tick vector. The transmission …

Borrelia burgdorferi, the causative agent of Lyme disease (along with closely related
genospecies), is in the deeply branching spirochete phylum. The bacterium is maintained in …

To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

As the Lyme disease bacterium Borrelia burgdorferi traverses its enzootic cycle, alternating
between a tick vector and a vertebrate host, the spirochete must adapt and persist in the tick …

Borrelia burgdorferi, the Lyme disease spirochete, couples environmental sensing and gene
regulation primarily via the Hk1/Rrp1 two-component system (TCS) and Rrp2/RpoN/RpoS …

ABSTRACT The Lyme disease bacterium Borrelia burgdorferi is extremely host dependent,
with a small genome and correspondingly limited metabolism. As such, it is an excellent …

The RpoS transcription factor of B orrelia burgdorferi is a 'gatekeeper'because it activates
genes required for spirochaetes to transition from tick to vertebrate hosts. However, it …

Background Lyme disease is the most prevalent vector-borne disease in the US, yet its host
factors are poorly understood and diagnostic tests are limited. We evaluated patients in a …