Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical
endocytosis of filtered proteins and small bioactive molecules from the glomerular …

Albumin is the main protein of blood plasma, lymph, cerebrospinal and interstitial fluid. The
protein participates in a variety of important biological functions, such as maintenance of …

The renal proximal tubule epithelium is responsible for active secretion of endogenous and
exogenous waste products from the body and simultaneous reabsorption of vital compounds …

Renal proximal tubule cells (PTECs) act as urine gatekeepers, constantly and efficiently
avoiding urinary protein waste through receptor-mediated endocytosis. Despite its …

Hypertensive individuals are at greater risk for developing chronic kidney disease (CKD).
Reducing proteinuria has been suggested as a possible therapeutic approach to treat CKD …

The megalin/cubilin complex is responsible for the majority of serum protein reclamation in
the proximal tubules. The current study examined if decreases in their renal expression …

Human serum albumin (HSA) is a natural carrier protein possessing multiple ligand binding
sites with a plasma half-life~ 19 days, facilitated by interaction with the human neonatal Fc …

Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor
serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic …

Diabetes mellitus (DM) has become an epidemic, causing a significant decline in quality of
life of individuals due to its multisystem involvement. Kidney is an important target organ in …

Myosin VI ensembles on endocytic cargo facilitate directed transport through a dense
cortical actin network. Myosin VI is recruited to clathrin-coated endosomes via the cargo …