Role of liver sinusoidal endothelial cells in liver diseases
J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …
other capillaries, they lack an organized basement membrane and have cytoplasm that is …
COVID-19 and thrombosis: From bench to bedside
MAM Ali, SA Spinler - Trends in cardiovascular medicine, 2021 - Elsevier
Abstract Coronavirus disease of 2019 (COVID-19) is the respiratory viral infection caused by
the coronavirus SARS-CoV2 (Severe Acute Respiratory Syndrome Coronavirus 2). Despite …
the coronavirus SARS-CoV2 (Severe Acute Respiratory Syndrome Coronavirus 2). Despite …
Endothelial cell control of thrombosis
Hemostasis encompasses a set of tightly regulated processes that govern blood clotting,
platelet activation, and vascular repair. Upon vascular injury, the hemostatic system initiates …
platelet activation, and vascular repair. Upon vascular injury, the hemostatic system initiates …
Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy
MJ McConnell, N Kawaguchi, R Kondo, A Sonzogni… - Journal of …, 2021 - Elsevier
Background and Aims COVID-19 is associated with liver injury and elevated interleukin-6 (IL-
6). We hypothesized that IL-6 trans-signaling in liver sinusoidal endothelial cells (LSECs) …
6). We hypothesized that IL-6 trans-signaling in liver sinusoidal endothelial cells (LSECs) …
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
JD Malhotra, H Miao, K Zhang… - Proceedings of the …, 2008 - National Acad Sciences
Protein misfolding in the endoplasmic reticulum (ER) contributes to the pathogenesis of
many diseases. Although oxidative stress can disrupt protein folding, how protein misfolding …
many diseases. Although oxidative stress can disrupt protein folding, how protein misfolding …
CD157 marks tissue-resident endothelial stem cells with homeostatic and regenerative properties
The generation of new blood vessels via angiogenesis is critical for meeting tissue oxygen
demands. A role for adult stem cells in this process remains unclear. Here, we identified …
demands. A role for adult stem cells in this process remains unclear. Here, we identified …
Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A
A normal hemostatic response to vascular injury requires both factor VIII (FVIII) and von
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …
Prominent receptors of liver sinusoidal endothelial cells in liver homeostasis and disease
E Pandey, AS Nour, EN Harris - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …
Interleukin 6 and haemostasis.
R Kerr, D Stirling, CA Ludlam - British journal of …, 2001 - search.ebscohost.com
Review Page 1 British Journal of Haematology, 2001, 115, 3ą12 Review INTERLEUKIN 6 AND
HAEMOSTASIS Interleukin 6 (IL-6) is a 26 kDa protein produced by many cell types including …
HAEMOSTASIS Interleukin 6 (IL-6) is a 26 kDa protein produced by many cell types including …
Murine coagulation factor VIII is synthesized in endothelial cells
LA Everett, ACA Cleuren, RN Khoriaty… - Blood, The Journal of …, 2014 - ashpublications.org
The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with
contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo …
contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo …