Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

[HTML][HTML] Virulence factors in hypervirulent Klebsiella pneumoniae

J Zhu, T Wang, L Chen, H Du - Frontiers in microbiology, 2021 - frontiersin.org
Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the
Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae …

Global spread and evolutionary convergence of multidrug-resistant and hypervirulent Klebsiella pneumoniae high-risk clones

G Arcari, A Carattoli - Pathogens and Global Health, 2023 - Taylor & Francis
For people living in developed countries life span is growing at a faster pace than ever. One
of the main reasons for such success is attributable to the introduction and extensive use in …

Galleria mellonella as an infection model: an in-depth look at why it works and practical considerations for successful application

MF Pereira, CC Rossi, GC da Silva… - Pathogens and …, 2020 - academic.oup.com
The larva of the greater wax moth Galleria mellonella is an increasingly popular model for
assessing the virulence of bacterial pathogens and the effectiveness of antimicrobial agents …

[HTML][HTML] Prophylaxis and Treatment against Klebsiella pneumoniae: Current Insights on This Emerging Anti-Microbial Resistant Global Threat

V Arato, MM Raso, G Gasperini… - International Journal of …, 2021 - mdpi.com
Klebsiella pneumoniae (Kp) is an opportunistic pathogen and the leading cause of
healthcare-associated infections, mostly affecting subjects with compromised immune …

[HTML][HTML] An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China

Y Zhao, X Zhang, VVL Torres, H Liu, A Rocker… - Frontiers in Public …, 2019 - frontiersin.org
Carbapenem-resistant, hypervirulent Klebsiella pneumoniae (CR-hvKP) has recently
emerged as a significant threat to public health. In this study, 29 K. pneumoniae isolates …

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae

J He, Q Shi, Z Chen, W Zhang, P Lan, Q Xu, H Hu… - Drug Resistance …, 2023 - Elsevier
Aims To investigate the in vivo evolution of the mucoid-phenotype of ST11-KL64
carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the same patients and …

[HTML][HTML] Global evolution of pathogenic bacteria with extensive use of fluoroquinolone agents

M Fuzi, J Rodriguez Baño, A Toth - Frontiers in microbiology, 2020 - frontiersin.org
It is well-established that the spread of many multidrug-resistant (MDR) bacteria is
predominantly clonal. Interestingly the international clones/sequence types (STs) of most …

[HTML][HTML] Emergence of a Hypervirulent Tigecycline-Resistant Klebsiella pneumoniae Strain Co-producing blaNDM–1 and blaKPC–2 With an Uncommon …

J Hao, B Zhang, J Deng, Y Wei, X Xiao… - Frontiers in Microbiology, 2022 - frontiersin.org
Emergence of bla NDM–1 and bla KPC–2 co-producing Klebsiella pneumoniae strains is
currently attracting widespread attention, but little information is available about their …

[HTML][HTML] Comparative in silico characterization of Klebsiella pneumoniae hypervirulent plasmids and their antimicrobial resistance genes

N Bolourchi, A Naz, M Sohrabi, F Badmasti - Annals of Clinical …, 2022 - Springer
Background The hypervirulent pathotype of Klebsiella pneumoniae (hvKp) is mainly
mediated by large virulent plasmids. It seems that these hypervirulent plasmids (HVPs) are …