The availability of combined antiretroviral therapy (cART) has revolutionized the course of
HIV infection, suppressing HIV viremia, restoring the immune system, and improving the …

Human immunodeficiency virus type 1 (HIV-1) infection is a chronic disease without a known
cure. The advent of effective antiretroviral therapy (ART) has enabled people with HIV …

Viral invasion of target cells triggers an immediate intracellular host defense system aimed
at preventing further propagation of the virus. Viral genomes or early products of viral …

Although combined antiretroviral therapy (cART) is effective in inhibiting human
immunodeficiency virus type 1 (HIV-1) replication, it does not eradicate the virus because …

Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is
not curative. The major barrier to finding a definitive cure for HIV is our inability to identify …

Autophagy has emerged as an integral part of the antiviral innate immune defenses,
targeting viruses or their components for lysosomal degradation. Thus, successful viruses …

Tripartite motif-containing protein 5α (TRIM5α) is generally known to block the postentry
events of HIV-1. Here, we report an uncharacterized role for TRIM5α in the maintenance of …

Recently, several studies have highlighted a skewed prevalence of infectious diseases
within the African continent. Furthermore, a growing number of studies have demonstrated …

Human cells are equipped with a plethora of antiviral proteins protecting them against
invading viral pathogens. In contrast to apoptotic or pyroptotic cell death, which serves as …

Highlights•Viruses hijack selected restriction factors for efficient replication.•Factors
promoting viral entry may in turn impair virion release and infectivity.•Endogenous and …