Post-translational modifications of cGAS-STING: A critical switch for immune regulation
Y Yu, J Liu, C Liu, R Liu, L Liu, Z Yu, J Zhuang, C Sun - Cells, 2022 - mdpi.com
Innate immune mechanisms initiate immune responses via pattern-recognition receptors
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …
Overview on chikungunya virus infection: from epidemiology to state-of-the-art experimental models
LEC Constant, BF Rajsfus, PH Carneiro… - Frontiers in …, 2021 - frontiersin.org
Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public
health. It is a member of the Togaviridae family and alphavirus genus and causes an …
health. It is a member of the Togaviridae family and alphavirus genus and causes an …
Differential roles of RIG-I like receptors in SARS-CoV-2 infection
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5
(MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate …
(MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate …
Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
RNA viruses continue to remain a threat for potential pandemics due to their rapid evolution.
Potentiating host antiviral pathways to prevent or limit viral infections is a promising strategy …
Potentiating host antiviral pathways to prevent or limit viral infections is a promising strategy …
Interplay between RNA viruses and cGAS/STING axis in innate immunity
While the function of cGAS/STING signalling axis in the innate immune response to DNA
viruses is well deciphered, increasing evidence demonstrates its significant contribution in …
viruses is well deciphered, increasing evidence demonstrates its significant contribution in …
Crosstalk between RNA viruses and DNA sensors: Role of the cGAS‐STING signalling pathway
Despite only comprising half of all known viral species, RNA viruses are disproportionately
responsible for many of the worst epidemics in human history, including outbreaks of …
responsible for many of the worst epidemics in human history, including outbreaks of …
Multifaceted roles of chemokine CXC motif ligand 7 in inflammatory diseases and cancer
Q Wu, H Tu, J Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Over recent years, CXC motif ligand 7 (CXCL7) has received widespread attention as a
chemokine involved in inflammatory responses. Abnormal production of the chemokine …
chemokine involved in inflammatory responses. Abnormal production of the chemokine …
Distinct cellular tropism and immune responses to alphavirus infection
Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging
from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic …
from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic …
Characterization of STING from common carp (Cyprinus carpio L.) involved in spring viremia of carp virus infection
R Liu, F Meng, X Li, H Li, G Yang, S Shan - Fish & Shellfish Immunology, 2023 - Elsevier
Stimulator of interferon genes (STING) serve as an endoplasmic reticulum (ER) protein and
modulates innate immune responses to viral contagion. Most investigations involving teleost …
modulates innate immune responses to viral contagion. Most investigations involving teleost …
Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model
Introduction An adult wild-type C57BL/6J mouse model of chikungunya virus (CHIKV)
infection and disease has been extensively used to study the alphaviral arthritic …
infection and disease has been extensively used to study the alphaviral arthritic …