The pharmacological treatment of cancer-related pain is unsatisfactory. Tetrodotoxin (TTX)
has shown analgesia in preclinical models and clinical trials, but its clinical efficacy and …

Pain is one of the most burdensome symptoms in people with cancer, and opioid analgesics
are considered the mainstay of cancer pain management. For this review, the authors …

Bone metastases frequently occur in patients with cancer. Skeletal-related events (SREs),
including pain, impaired mobility, hypercalcemia, pathological fracture, spinal cord and …

Purpose We investigated whether twice-daily administration of a bilayer tablet formulation of
tramadol (35% immediate-release [IR] and 65% sustained-release) is as effective as four …

Abstract Study Objective Few data are available on the association between the use of
oxycodone in patients with chronic kidney disease (CKD) and acute respiratory conditions …

Purpose Breast cancer is the most common cancer among Japanese women and often
yields a better prognosis than other cancers. However, few studies have been conducted on …

Introduction Opioid-induced constipation (OIC) is one of the most common side effects in
patients with cancer treated with opioid analgesics. The actual use of laxatives for OIC in …

Background Cancer patients often have impaired renal and hepatic function. Opioids are
essential to relieve painful symptoms in cancer patients. However, it is unknown which …

Background and Objective: Opioid-induced nausea and vomiting (OINV) is known to
develop not only upon opioid introduction but also during opioid dose escalation, but the …

Context Cancer pain is a common complication that is frequently undertreated in patients
with cancer. Objectives This study is aimed at assessing the time needed to achieve cancer …