Molecular biomarkers in cancer

VK Sarhadi, G Armengol - Biomolecules, 2022 - mdpi.com
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …

Large-scale single-cell and bulk sequencing analyses reveal the prognostic value and immune aspects of CD147 in pan-cancer

J Zhang, Z Wang, X Zhang, Z Dai, W Zhi-Peng… - Frontiers in …, 2022 - frontiersin.org
CD147 plays an important role in promoting tumor proliferation and inhibiting cancer cell
apoptosis in the tumor microenvironment. However, the mechanisms by which CD147 is …

Intrinsic molecular subtypes of metastatic castration-resistant prostate cancer

E Feng, NR Rydzewski, M Zhang, A Lundberg… - Clinical Cancer …, 2022 - AACR
Purpose: Although numerous biology-driven subtypes have been described previously in
metastatic castration-resistant prostate cancer (mCRPC), unsupervised molecular subtyping …

Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone

H Bakhtiar, KT Helzer, Y Park, Y Chen… - NPJ Genomic …, 2022 - nature.com
DNA mutations in specific genes can confer preferential benefit from drugs targeting those
genes. However, other molecular perturbations can “phenocopy” pathogenic mutations, but …

Pan-cancer and single-cell analysis reveal the prognostic value and immune response of NQO1

L Shen, S Jiang, Y Yang, H Yang, Y Fang… - Frontiers in Cell and …, 2023 - frontiersin.org
Background: Overexpression of the NAD (P) H: Quinone Oxidoreductase 1 (NQOI) gene has
been linked with tumor progression, aggressiveness, drug resistance, and poor patient …

[HTML][HTML] Pan-cancer analysis of the immune aspects and prognostic value of NCAPG2

H Feng, N Chen, H Li, Z Zheng, H Li, H Quan, X Jin… - Heliyon, 2023 - cell.com
NCAPG2 has been reported to be associated with tumorigenesis in various types of cancer.
However, data on the pathological mechanisms of NCAPG2 in pan-cancers remain lacking …

[PDF][PDF] Molecular Biomarkers in Cancer. Biomolecules 2022, 12, 1021

VK Sarhadi, G Armengol - 2022 - helda.helsinki.fi
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …

Deep pan-cancer analysis and multi-omics evidence reveal that ALG3 inhibits CD8+ T cell infiltration by suppressing chemokine secretion and is associated with 5 …

Z Wu, R Su, Y Dai, X Wu, H Wu, X Wang… - Computers in Biology …, 2024 - Elsevier
Abstract Background α-1, 3-mannosyltransferase (ALG3) holds significance as a key
member within the mannosyltransferase family. Nevertheless, the exact function of ALG3 in …

The role of FERMT2 in the tumor microenvironment and immunotherapy in pan-cancer using comprehensive single-cell and bulk sequencing

G Wu, C He, G Che, Z Zhou, B Chen, H Wu, J Chen… - Heliyon, 2024 - cell.com
FERMT2 has been identified as a participant in integrin-linked kinase signaling pathways,
influencing epithelial-mesenchymal transition and thereby affecting tumor initiation …

[HTML][HTML] Tumor Morphology for Prediction of Poor Responses Early in Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter Retrospective Study

W Li, NN Le, R Nadkarni, N Onishi, LJ Wilmes… - Tomography, 2024 - mdpi.com
Background: This multicenter and retrospective study investigated the additive value of
tumor morphologic features derived from the functional tumor volume (FTV) tumor mask at …