Triterpenoids are a class of natural products widely used in fields related to medicine and
health due to their biological activities such as hepatoprotection, anti-inflammation, anti-viral …

Covering: up to May 2020 Oxidosqualene cyclases (OSCs) catalyze one of the most
complex polycyclization reactions in nature, using the linear 2, 3-oxidosqualene to generate …

Abstract Motivation Multiple sequence alignments (MSAs) of homologous sequences
contain information on structural and functional constraints and their evolutionary histories …

Gene duplication is assumed to be the major force driving the evolution of metabolite
biosynthesis in plants. Freed from functional burdens, duplicated genes can mutate toward …

Triterpenoids are biologically active metabolites synthesized from a common linear
precursor catalyzed by 2, 3-oxidosqualene cyclases (OSCs) to form diverse triterpenoid …

The vast majority of structurally diverse metabolites play essential roles in mediating the
interactions between plant and environment, and constitute a valuable resource for …

Functional manipulation of biosynthetic enzymes such as cytochrome P450s (or P450s) has
attracted great interest in metabolic engineering of plant natural products. Cucurbitacins and …

Potato is one of the most important crops worldwide, to feed a fast-growing population. In
addition to providing energy, fiber, vitamins, and minerals, potato storage proteins are …

Cytochrome P450s (P450s) are the most versatile catalysts utilized by plants to produce
structurally and functionally diverse metabolites. Given the high degree of gene redundancy …

The exponential growth of protein sequences in the post-genomic era has revolutionized the
application of generative sequence models for pivotal tasks such as contact prediction …