The temperature dependence of sleep
Mammals have evolved a range of behavioural and neurological mechanisms that
coordinate cycles of thermoregulation and sleep. Whether diurnal or nocturnal, sleep onset …
coordinate cycles of thermoregulation and sleep. Whether diurnal or nocturnal, sleep onset …
The significance of meaning: why do over 90% of behavioral neuroscience results fail to translate to humans, and what can we do to fix it?
JP Garner - ILAR journal, 2014 - academic.oup.com
The vast majority of drugs entering human trials fail. This problem (called “attrition”) is widely
recognized as a public health crisis, and has been discussed openly for the last two …
recognized as a public health crisis, and has been discussed openly for the last two …
The 3Rs and humane experimental technique: implementing change
RC Hubrecht, E Carter - Animals, 2019 - mdpi.com
Simple Summary The 3Rs: Replacement, Reduction and Refinement, formulated by William
Russell and Rex Burch, have become synonymous with the measures to improve the …
Russell and Rex Burch, have become synonymous with the measures to improve the …
Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis
Background Over 120 million mice and rats are used annually in research, conventionally
housed in shoebox-sized cages that restrict natural behaviours (eg nesting and burrowing) …
housed in shoebox-sized cages that restrict natural behaviours (eg nesting and burrowing) …
[HTML][HTML] Commonly used animal models
DL Hickman, J Johnson, TH Vemulapalli… - Principles of animal …, 2017 - ncbi.nlm.nih.gov
This chapter provides an introduction to animals that are commonly used for research. It
presents information on basic care topics such as biology, behavior, housing, feeding …
presents information on basic care topics such as biology, behavior, housing, feeding …
[HTML][HTML] Sleep and thermoregulation
In homeothermic animals sleep preparatory behaviours often promote thermal efficiency,
including warmth-seeking, adopting particular postures (curling up, head tucking) and nest …
including warmth-seeking, adopting particular postures (curling up, head tucking) and nest …
Introducing Therioepistemology: the study of how knowledge is gained from animal research
This focus issue of Lab Animal coincides with a tipping point in biomedical research. For the
first time, the scale of the reproducibility and translatability crisis is widely understood …
first time, the scale of the reproducibility and translatability crisis is widely understood …
[HTML][HTML] Rats and mice
J Frohlich - Ferrets, rabbits, and rodents, 2020 - ncbi.nlm.nih.gov
This chapter provides an overview of the natural history, anatomy, physiology, clinical
examination, common diseases, and treatment of rats (Rattus norvegicus) and mice (Mus …
examination, common diseases, and treatment of rats (Rattus norvegicus) and mice (Mus …
[HTML][HTML] Neuron-specific Kv1. 1 deficiency is sufficient to cause epilepsy, premature death, and cardiorespiratory dysregulation
K Trosclair, HA Dhaibar, NM Gautier, V Mishra… - Neurobiology of …, 2020 - Elsevier
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related
mortality, but the precise cellular substrates involved remain elusive. Epilepsy-associated …
mortality, but the precise cellular substrates involved remain elusive. Epilepsy-associated …
The epidemiology of fighting in group-housed laboratory mice
Injurious home-cage aggression (fighting) in mice affects both animal welfare and scientific
validity. It is arguably the most common potentially preventable morbidity in mouse facilities …
validity. It is arguably the most common potentially preventable morbidity in mouse facilities …