Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Cardiac arrhythmia is one of the most prevalent cardiovascular diseases worldwide, which
can occur alone or be triggered by other diseases, and it can be fatal in severe cases …

The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …

Abstract Objectives/Aims Inflammation is crucial in structural and electrical remodeling after
myocardial infarction (MI), affecting cardiac pump function and conduction pathways …

Abstract Myocardial connexin 43 (Cx43) forms gap junctions and hemichannels, and is also
present within subsarcolemmal mitochondria. The protein is phosphorylated by several …

Heart diseases and related complications constitute a leading cause of death and
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …

Gap junctions and their expression pattern are essential to robust function of intercellular
communication and electrical propagation in cardiomyocytes. In healthy myocytes, the main …

The prevalence of atrial fibrillation (AF) is bound to increase globally in the following years,
affecting the quality of life of millions of people, increasing mortality and morbidity, and …

Heart failure (HF) is life-threatening disease due to electro-mechanical dysfunction
associated with hemodynamic overload, while alterations of extracellular matrix (ECM) …

Aging comes with gradual loss of functions that increase the vulnerability to disease,
senescence, and death. The mechanisms underlying these processes are linked to a …