Artificial intelligence in drug discovery and development

KK Mak, YH Wong, MR Pichika - Drug Discovery and Evaluation: Safety …, 2023 - Springer
This chapter comprehensively explores the pivotal role of artificial intelligence (AI) in drug
discovery and development, encapsulating its potentials, methodologies, real-world …

A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis

P Coto-Segura, C Segú-Vergés, A Martorell… - Frontiers in …, 2023 - frontiersin.org
Background Psoriasis is a chronic immune-mediated inflammatory systemic disease with
skin manifestations characterized by erythematous, scaly, itchy and/or painful plaques …

Advancing treatment of retinal disease through in silico trials

RJ Hernandez, PA Roberts… - Progress in Biomedical …, 2023 - iopscience.iop.org
Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …

Addressing the Treatment and Service Needs of Young Adults with Attention Deficit Hyperactivity Disorder

J Quintero, A Rodríguez-Quiroga… - Child and …, 2022 - childpsych.theclinics.com
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder
characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity that …

[HTML][HTML] Unveiling chronic spontaneous urticaria pathophysiology through systems biology

C Segú-Vergés, J Gómez, P Terradas-Montana… - Journal of Allergy and …, 2023 - Elsevier
Background Chronic spontaneous urticaria (CSU) is a rare, heterogeneous, severely
debilitating, and often poorly controlled skin disease resulting in an itchy eruption which can …

Cost-effectiveness and budget impact analysis of lisdexamfetamine versus methylphenidate for patients under 18 with attention-deficit/hyperactivity disorder in Iran

A Tajik, S Nikfar, S Elyasi, O Rajabi… - Child and Adolescent …, 2023 - Springer
Abstract Background Lisdexamfetamine (LDX) and Methylphenidate (MPH) are stimulant
agents that have been shown to provide significant benefits in the management of attention …

Computer-aided drug design (cadd) to de-orphanize marine molecules: finding potential therapeutic agents for neurodegenerative and cardiovascular diseases

L Llorach-Pares, A Nonell-Canals, C Avila… - Marine Drugs, 2022 - mdpi.com
Computer-aided drug design (CADD) techniques allow the identification of compounds
capable of modulating protein functions in pathogenesis-related pathways, which is a …

A decision support system based on artificial intelligence and systems biology for the simulation of pancreatic cancer patient status

V Junet, P Matos‐Filipe… - CPT …, 2023 - Wiley Online Library
Oncology treatments require continuous individual adjustment based on the measurement
of multiple clinical parameters. Prediction tools exploiting the patterns present in the clinical …

In Silico Clinical Trials: Is It Possible?

S Arsene, Y Pares, E Tixier, S Granjeon-Noriot… - … Computing for Drug …, 2023 - Springer
Modeling and simulation (M&S), including in silico (clinical) trials, helps accelerate drug
research and development and reduce costs and have coined the term “model-informed …

In silico clinical trial evaluating lisdexamfetamine's and methylphenidate's mechanism of action computational models in an attention-deficit/hyperactivity disorder …

JR Gutiérrez-Casares, J Quintero… - Frontiers in …, 2023 - frontiersin.org
Introduction Attention-deficit/hyperactivity disorder (ADHD) is an impairing psychiatric
condition with the stimulants, lisdexamfetamine (LDX), and methylphenidate (MPH), as the …