The immune system evolved to distinguish non-self from self to protect the organism. As
cancer is derived from our own cells, immune responses to dysregulated cell growth present …

Purpose Vitiligo-like depigmentation in patients with melanoma may be associated with
more favorable clinical outcome. We conducted a systematic review of patients with stage III …

Identifying tumor antigen-specific T cells from cancer patients has important implications for
immunotherapy diagnostics and therapeutics. Here, we show that CD103+ CD39+ tumor …

Therapeutic ex vivo T-cell expansion is limited by low rates and T-cell products of limited
functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) …

Our bodies are equipped with powerful immune surveillance to clear cancerous cells as they
emerge. How tumor-initiating stem cells (tSCs) that form and propagate cancers equip …

Purpose: Despite favorable responses of chimeric antigen receptor (CAR)-engineered T-cell
therapy in patients with hematologic malignancies, the outcome has been far from …

Recent years have seen a renaissance in the research linking inflammation and cancer with
immune cells playing a central role in smouldering inflammation in the tumor …

Abstract Of the~ 129,079 new cases of nasopharyngeal carcinoma (NPC) and 72,987
associated deaths estimated for 2018, the majority will be geographically localized to South …

Purpose: Adoptive T-cell immunotherapy with tumor infiltrating lymphocytes or genetically-
modified T cells has yielded dramatic results in some cancers. However, T cells need to …

We developed an in vitro method for isolating and expanding autologous CD4+ T-cell
clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these …