Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …

Thirty years ago, there was an emerging appreciation for the significance of oxidative stress
in newborn disease. This prompted a renewed interest in the impact of oxygen therapy for …

Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …

Significance: Fluorescent protein sensors have revitalized the field of redox biology by
revolutionizing the study of redox processes in living cells and organisms. Recent Advances …

Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Mitochondria are responsible for the majority of oxygen consumption in cells, and thus
represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years …

Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
On binding of NO to its prosthetic haem group, sGC catalyses the synthesis of the second …

Pulmonary hypertension (PH) is a common complication of neonatal respiratory diseases,
including bronchopulmonary dysplasia (BPD), and recent studies have increased …

Persistent pulmonary hypertension of the newborn (PPHN) is a significant clinical problem
characterized by refractory and severe hypoxemia secondary to elevated pulmonary …