In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI)
responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity …

In the embryonic heart, electrical impulses propagate in a unidirectional manner from the
sinus venosus and appear to be involved in cardiogenesis. In this work, aligned and random …

Abstract Ischemic Heart Disease (IHD) still represents the “Number One Killer” worldwide
accounting for the death of numerous patients. However the capacity for self-regeneration of …

The complex and highly organized environment in which cells reside consists primarily of
the extracellular matrix (ECM) that delivers biological signals and physical stimuli to resident …

The efficacy of a pharmaceutical treatment is often countered by the inadequate membrane
permeability, that prevents drugs from reaching their specific intracellular targets. Cell …

The application of biomimetic physical stimuli replicating the in vivo dynamic
microenvironment is crucial for the in vitro development of functional cardiac tissues. In …

Cardiovascular disease (CVD) is the number one cause of death in the United States.
However, few treatments for CVD provide a means to regain full cardiac function with no …

In the past two decades, relevant advances have been made in the generation of
engineered cardiac constructs to be used as functional in vitro models for cardiac research …