Measuring DNA modifications with the comet assay: a compendium of protocols

A Collins, P Møller, G Gajski, S Vodenková… - Nature protocols, 2023 - nature.com
The comet assay is a versatile method to detect nuclear DNA damage in individual
eukaryotic cells, from yeast to human. The types of damage detected encompass DNA …

An overview of comet assay application for detecting DNA damage in aquatic animals

N Jiang, S Naz, Y Ma, Q Ullah, MZ Khan, J Wang, X Lu… - Agriculture, 2023 - mdpi.com
This review discusses several research studies that employed comet assay to evaluate the
environmental impact of genotoxins in aquatic environments. It focuses on in vivo and in situ …

Catalase‐Mimetic Artificial Biocatalysts with Ru Catalytic Centers for ROS Elimination and Stem‐Cell Protection

Y Sun, S Mu, Z Xing, J Guo, Z Wu, F Yu… - Advanced …, 2022 - Wiley Online Library
Exploring high‐efficiency reactive oxygen species (ROS)‐elimination materials is of great
importance for combating oxidative stress in diverse diseases, especially stem‐cell‐based …

Genotoxicity of particles from grinded plastic items in Caco-2 and HepG2 cells

M Roursgaard, M Hezareh Rothmann… - Frontiers in Public …, 2022 - frontiersin.org
Large plastic litters degrade in the environment to micro-and nanoplastics, which may then
enter the food chain and lead to human exposure by ingestion. The present study explored …

DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

S Bonassi, M Ceppi, P Møller, A Azqueta, M Milić… - Scientific Reports, 2021 - nature.com
The comet assay or single cell gel electrophoresis, is the most common method used to
measure strand breaks and a variety of other DNA lesions in human populations. To …

[HTML][HTML] Biomarkers of nucleic acid oxidation–A summary state-of-the-art

MR Chao, MD Evans, CW Hu, Y Ji, P Møller, P Rossner… - Redox Biology, 2021 - Elsevier
Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide
variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the …

Stress driven discovery of natural products from actinobacteria with anti-oxidant and cytotoxic activities including docking and admet properties

SS Hassan, I Muhammad, SQ Abbas… - International Journal of …, 2021 - mdpi.com
Elicitation through abiotic stress, including chemical elicitors like heavy metals, is a new
technique for drug discovery. In this research, the effect of heavy metals on actinobacteria …

FLASH irradiation induces lower levels of DNA damage ex vivo, an effect modulated by oxygen tension, dose, and dose rate

CR Cooper, D Jones, GDD Jones… - The British Journal of …, 2022 - academic.oup.com
Objective: FLASH irradiation reportedly produces less normal tissue toxicity, while
maintaining tumour response. To investigate oxygen's role in the 'FLASH effect', we …

Imidacloprid: Comparative toxicity, DNA damage, ROS production and risk assessment for aquatic non-target organisms

R Nugnes, C Russo, E Orlo, M Lavorgna… - Environmental Pollution, 2023 - Elsevier
Imidacloprid is a neonicotinoid systemic insecticide used worldwide. Despite its hazardous
impact on non-target organisms, few studies have been conducted concerning the potential …

[HTML][HTML] Adverse (geno) toxic effects of bisphenol A and its analogues in hepatic 3D cell model

M Sendra, M Štampar, K Fras, B Novoa… - Environment …, 2023 - Elsevier
Bisphenol A (BPA) is one of the most widely used and versatile chemical compounds in
polymer additives and epoxy resins for manufacturing a range of products for human …